Potential anti-SARS-CoV-2 prodrugs activated by phosphorylation and their role in the aged population

VP Chavda, D Teli, PC Balar, D Vaghela, HK Solanki… - Molecules, 2023 - mdpi.com
The COVID-19 pandemic has flared across every part of the globe and affected populations
from different age groups differently. People aged from 40 to 80 years or older are at an …

The relationship between viral clearance rates and disease progression in early symptomatic COVID-19: a systematic review and meta-regression analysis

S Singh, S Boyd, WHK Schilling… - Journal of …, 2024 - academic.oup.com
Background Effective antiviral drugs accelerate viral clearance in acute COVID-19
infections; the relationship between accelerating viral clearance and reducing severe …

Clinical antiviral efficacy of favipiravir in early COVID-19 (PLATCOV): an open-label, randomised, controlled, adaptive platform trial

V Luvira, WHK Schilling, P Jittamala, JA Watson… - BMC Infectious …, 2024 - Springer
Brief summary In early symptomatic COVID-19 treatment, high dose oral favipiravir did not
accelerate viral clearance. Background Favipiravir, an anti-influenza drug, has in vitro …

[HTML][HTML] Efficacy of Andrographis paniculata extract treatment in mild to moderate COVID-19 patients being treated with favipiravir: A double-blind, randomized …

T Siripongboonsitti, T Ungtrakul, K Tawinprai… - Phytomedicine, 2023 - Elsevier
Background While favipiravir had been the standard anti-SARS-CoV-3 drug for COVID-19
treatment in Thailand, the efficacy of favipiravir treatment is controversial. Andrographis …

Molecular insights into the sensing function of an oxidized graphene flake for the adsorption of Avigan antiviral drug

RDC Pecho, N Hajali, RD Tapia-Silguera… - Computational and …, 2023 - Elsevier
The Avigan antiviral drug adsorption by an oxidized form of a graphene flake; so called
Ovalene, was investigated using density functional theory calculations to provide molecular …

Oral Favipiravir Exposure and Pharmacodynamic Effects in Adult Outpatients With Acute Influenza

FG Hayden, RP Lenk, C Epstein… - The Journal of Infectious …, 2023 - academic.oup.com
Background The pharmacokinetics of oral favipiravir and the relationships of plasma
concentrations to antiviral effects are incompletely studied in influenza. Methods Serial …

[HTML][HTML] Development and validation of an LC-MS/MS method for quantification of favipiravir in human plasma

E Challenger, SD Penchala, C Hale… - … of pharmaceutical and …, 2023 - Elsevier
Favipiravir (FVP) is a broad-spectrum antiviral that selectively inhibits viral RNA-dependent
RNA polymerase, first trialled for the treatment of influenza infection. It has been shown to be …

Mapping the Lipid Signatures in COVID-19 Infection: Diagnostic and Therapeutic Solutions

A Dasgupta, S Gangai, R Narayan… - Journal of Medicinal …, 2023 - ACS Publications
The COVID-19 pandemic ignited research centered around the identification of robust
biomarkers and therapeutic targets. SARS-CoV-2, the virus responsible, hijacks the …

Favipiravir treatment in non-severe COVID-19: promising results from multicenter propensity score-matched study (FAVICOV)

T Siripongboonsitti, M Muadchimkaew, K Tawinprai… - Scientific Reports, 2023 - nature.com
This study aimed to evaluate the efficacy of favipiravir (FPV) in preventing the development
of severe COVID-19 in patients with mild-to-moderate symptoms. The study evaluated 1037 …

Aprotinin—Drug against respiratory diseases

AV Ivachtchenko, AA Ivashchenko, DO Shkil… - International Journal of …, 2023 - mdpi.com
Aprotinin (APR) was discovered in 1930. APR is an effective pan-protease inhibitor, a typical
“magic shotgun”. Until 2007, APR was widely used as an antithrombotic and anti …