Interaction of SARS-CoV-2 with host cells and antibodies: experiment and simulation
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …
Interactions of angiotensin-converting enzyme-2 (ACE2) and SARS-CoV-2 spike receptor-binding domain (RBD): a structural perspective
Abstract Background Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has
caused millions of infections and deaths worldwide since its discovery in late 2019 in …
caused millions of infections and deaths worldwide since its discovery in late 2019 in …
[HTML][HTML] Variations within the glycan shield of SARS-CoV-2 impact viral spike dynamics
The emergence of SARS-CoV-2 variants alters the efficacy of existing immunity, whether
arisen naturally or through vaccination. Understanding the structure of the viral spike assists …
arisen naturally or through vaccination. Understanding the structure of the viral spike assists …
In situ structure and dynamics of an alphacoronavirus spike protein by cryo-ET and cryo-EM
Porcine epidemic diarrhea (PED) is a highly contagious swine disease caused by porcine
epidemic diarrhea virus (PEDV). PED causes enteric disorders with an exceptionally high …
epidemic diarrhea virus (PEDV). PED causes enteric disorders with an exceptionally high …
Analysis of the N-glycosylation profiles of the spike proteins from the Alpha, Beta, Gamma, and Delta variants of SARS-CoV-2
N-Glycosylation plays an important role in the structure and function of membrane and
secreted proteins. Viral proteins used in cell entry are often extensively glycosylated to assist …
secreted proteins. Viral proteins used in cell entry are often extensively glycosylated to assist …
Coronavirus accessory protein ORF3 biology and its contribution to viral behavior and pathogenesis
Coronavirus porcine epidemic diarrhea virus (PEDV) is classified in the genus
Alphacoronavirus, family Coronaviridae that encodes the only accessory protein, ORF3 …
Alphacoronavirus, family Coronaviridae that encodes the only accessory protein, ORF3 …
Rapid simulation of glycoprotein structures by grafting and steric exclusion of glycan conformer libraries
Most membrane proteins are modified by covalent addition of complex sugars through N-
and O-glycosylation. Unlike proteins, glycans do not typically adopt specific secondary …
and O-glycosylation. Unlike proteins, glycans do not typically adopt specific secondary …
Variations in O-Glycosylation Patterns Influence Viral Pathogenicity, Infectivity, and Transmissibility in SARS-CoV-2 Variants
The highly glycosylated S protein plays a vital role in host cell invasion, making it the
principal target for vaccine development. Differences in mutations observed on the spike (S) …
principal target for vaccine development. Differences in mutations observed on the spike (S) …
[HTML][HTML] Evolving spike-protein N-glycosylation in SARS-CoV-2 variants
Abstract Since> 3 years, SARS-CoV-2 has plunged humans into a colossal pandemic.
Henceforth, multiple waves of infection have swept through the human population, led by …
Henceforth, multiple waves of infection have swept through the human population, led by …
SP-A binding to the SARS-CoV-2 spike protein using hybrid quantum and classical in silico modeling and molecular pruning by Quantum Approximate Optimization …
S Aramyan, K McGregor, S Sandeep… - Frontiers in …, 2022 - frontiersin.org
The pulmonary surfactant protein A (SP-A) is a constitutively expressed immune-protective
collagenous lectin (collectin) in the lung. It binds to the cell membrane of immune cells and …
collagenous lectin (collectin) in the lung. It binds to the cell membrane of immune cells and …