Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

J Guo, X Huang, L Dou, M Yan, T Shen… - Signal Transduction and …, 2022 - nature.com
Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Current status of the diagnosis and management of osteoporosis

A Aibar-Almazán, A Voltes-Martínez… - International journal of …, 2022 - mdpi.com
Osteoporosis has been defined as the silent disease of the 21st century, becoming a public
health risk due to its severity, chronicity and progression and affecting mainly …

Osteoporosis pathogenesis and treatment: existing and emerging avenues

B Liang, G Burley, S Lin, YC Shi - Cellular & Molecular Biology Letters, 2022 - Springer
Osteoporotic fractures lead to increased disability and mortality in the elderly population.
With the rapid increase in the aging population around the globe, more effective treatments …

Advances in mesenchymal stem cell transplantation for the treatment of osteoporosis

Y Jiang, P Zhang, X Zhang, L Lv, Y Zhou - Cell proliferation, 2021 - Wiley Online Library
Osteoporosis is a systemic metabolic bone disease with characteristics of bone loss and
microstructural degeneration. The personal and societal costs of osteoporosis are …

Senile osteoporosis: the involvement of differentiation and senescence of bone marrow stromal cells

A Qadir, S Liang, Z Wu, Z Chen, L Hu… - International journal of …, 2020 - mdpi.com
Senile osteoporosis has become a worldwide bone disease with the aging of the world
population. It increases the risk of bone fracture and seriously affects human health. Unlike …

Cadmium toxicity: a role in bone cell function and teeth development

Y Ma, D Ran, X Shi, H Zhao, Z Liu - Science of The Total Environment, 2021 - Elsevier
Cadmium (Cd) is a widespread environmental contaminant that causes severe bone
metabolism disease, such as osteoporosis, osteoarthritis, and osteomalacia. The present …

NLRP3 inflammasome: a new target for prevention and control of osteoporosis?

N Jiang, J An, K Yang, J Liu, C Guan, C Ma… - Frontiers in …, 2021 - frontiersin.org
Osteoporosis is a systemic bone metabolism disease that often causes complications, such
as fractures, and increases the risk of death. The nucleotide-binding oligomerization domain …

Mitochondrial dynamics: fission and fusion in fate determination of mesenchymal stem cells

L Ren, X Chen, X Chen, J Li, B Cheng… - Frontiers in cell and …, 2020 - frontiersin.org
Mesenchymal stem cells (MSCs) are pivotal to tissue homeostasis, repair, and regeneration
due to their potential for self-renewal, multilineage differentiation, and immune modulation …

Molecular mechanisms of adipogenesis: the anti-adipogenic role of AMP-activated protein kinase

B Ahmad, CJ Serpell, IL Fong… - Frontiers in molecular …, 2020 - frontiersin.org
Obesity is now a widespread disorder, and its prevalence has become a critical concern
worldwide, due to its association with common co-morbidities like cancer, cardiovascular …

Mitochondrial transfer and regulators of mesenchymal stromal cell function and therapeutic efficacy

A Mohammadalipour, SP Dumbali… - Frontiers in Cell and …, 2020 - frontiersin.org
Mesenchymal stromal cell (MSC) metabolism plays a crucial role in the surrounding
microenvironment in both normal physiology and pathological conditions. While MSCs …