Wet granulation is a very important unit operation that finds applications in many industries
mainly pharmaceutical and chemical industries. Various granulation technologies in batch …

Continuous crystallization has always been a hot topic in industrial crystallization. Many
efforts have been made to improve the continuous crystallization, either by designing novel …

Manufacturing of powder-based products is a focus of increasing research in the recent
years. The main reason is the lack of predictive process models connecting process …

The pharmaceutical industry is under growing pressure to increase efficiency, both in
production and in process development. This paper discusses the central role of Process …

The manufacturing of pharmaceutical dosage forms, which has traditionally been a batch-
wise process, is now also transformed into a series of continuous operations. Some …

The objective of this work is to present a review of computational tools and models for
pharmaceutical processes, specifically those for the continuous manufacture of solid dosage …

In this study, a novel mechanistic model for a wet granulation process is presented,
combining the techniques of population balance modeling and discrete element methods to …

Wet granulation is a complex particle design process often operated inefficiently in industrial
applications. Enhanced process understanding is required to facilitate design, control, and …

In this study, a hybrid multi-scale model has been developed for a continuous fluid bed wet
granulation process by dynamically coupling computational fluid dynamics (CFD) with a …

Crystallization has been applied to a broad range of industries such as bulk and fine
chemicals and the pharmaceutical and food industries. It is important to strategically control …