[HTML][HTML] What genes are differentially expressed in individuals with schizophrenia? A systematic review
AK Merikangas, M Shelly, A Knighton, N Kotler… - Molecular …, 2022 - nature.com
Schizophrenia is a severe, complex mental disorder characterized by a combination of
positive symptoms, negative symptoms, and impaired cognitive function. Schizophrenia is …
positive symptoms, negative symptoms, and impaired cognitive function. Schizophrenia is …
[HTML][HTML] Clozapine as a model for antipsychotic development
FC Nucifora Jr, M Mihaljevic, BJ Lee, A Sawa - Neurotherapeutics, 2017 - Elsevier
Schizophrenia is a devastating illness that affects up to 1% of the population; it is
characterized by a combination of positive symptoms, negative symptoms, and cognitive …
characterized by a combination of positive symptoms, negative symptoms, and cognitive …
Gene expression elucidates functional impact of polygenic risk for schizophrenia
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …
The functional and evolutionary impacts of human-specific deletions in conserved elements
Conserved genomic sequences disrupted in humans may underlie uniquely human
phenotypic traits. We identified and characterized 10,032 human-specific conserved …
phenotypic traits. We identified and characterized 10,032 human-specific conserved …
The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing
G Barry, JA Briggs, DP Vanichkina, EM Poth… - Molecular …, 2014 - nature.com
Schizophrenia (SZ) is a complex disease characterized by impaired neuronal functioning.
Although defective alternative splicing has been linked to SZ, the molecular mechanisms …
Although defective alternative splicing has been linked to SZ, the molecular mechanisms …
Immune system disturbances in schizophrenia
Epidemiological, genetic, transcriptome, postmortem, peripheral biomarker, and therapeutic
studies of schizophrenia all point to a dysregulation of both innate and adaptive immune …
studies of schizophrenia all point to a dysregulation of both innate and adaptive immune …
Neuroimmune biomarkers in schizophrenia
J Tomasik, H Rahmoune, PC Guest, S Bahn - Schizophrenia Research, 2016 - Elsevier
Schizophrenia is a heterogeneous psychiatric disorder with a broad spectrum of clinical and
biological manifestations. Due to the lack of objective tests, the accurate diagnosis and …
biological manifestations. Due to the lack of objective tests, the accurate diagnosis and …
Glial cells as key players in schizophrenia pathology: recent insights and concepts of therapy
HG Bernstein, J Steiner, PC Guest, H Dobrowolny… - Schizophrenia …, 2015 - Elsevier
The past decade has witnessed an explosion of knowledge on the impact of glia for the
neurobiological foundation of schizophrenia. A plethora of studies have shown structural …
neurobiological foundation of schizophrenia. A plethora of studies have shown structural …
[HTML][HTML] Commonality in dysregulated expression of gene sets in cortical brains of individuals with autism, schizophrenia, and bipolar disorder
Individuals affected with different neuropsychiatric disorders such as autism (AUT),
schizophrenia (SCZ) and bipolar disorder (BPD), may share similar clinical manifestations …
schizophrenia (SCZ) and bipolar disorder (BPD), may share similar clinical manifestations …
Contrasting changes in DRD1 and DRD2 splice variant expression in schizophrenia and affective disorders, and associations with SNPs in postmortem brain
SS Kaalund, EN Newburn, T Ye, R Tao, C Li… - Molecular …, 2014 - nature.com
Abstract Dopamine 2 receptor (DRD2) is of major interest to the pathophysiology of
schizophrenia (SCZ) both as a target for antipsychotic drug action as well as a SCZ …
schizophrenia (SCZ) both as a target for antipsychotic drug action as well as a SCZ …