[HTML][HTML] Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets
M Farahani, Z Niknam, LM Amirabad… - Biomedicine & …, 2022 - Elsevier
Deciphering the molecular downstream consequences of severe acute respiratory
syndrome coronavirus (SARS-CoV)− 2 infection is important for a greater understanding of …
syndrome coronavirus (SARS-CoV)− 2 infection is important for a greater understanding of …
[HTML][HTML] The battle between host and SARS-CoV-2: Innate immunity and viral evasion strategies
The SARS-CoV-2 virus, the pathogen causing COVID-19, has caused more than 200 million
confirmed cases, resulting in more than 4.5 million deaths worldwide by the end of August …
confirmed cases, resulting in more than 4.5 million deaths worldwide by the end of August …
The therapeutic efficacy of quercetin in combination with antiviral drugs in hospitalized COVID-19 patients: A randomized controlled trial
In this study, the therapeutic efficacy of quercetin in combination with remdesivir and
favipiravir, were evaluated in severe hospitalized COVID-19 patients. Our main objective …
favipiravir, were evaluated in severe hospitalized COVID-19 patients. Our main objective …
Recent progress and prospects of small molecules for NLRP3 inflammasome inhibition
N Li, R Zhang, M Tang, M Zhao, X Jiang… - Journal of Medicinal …, 2023 - ACS Publications
NLRP3 inflammasome is a multiprotein complex involved in host immune response─ which
exerts various biological effects by mediating the maturation and secretion of IL-1β and IL …
exerts various biological effects by mediating the maturation and secretion of IL-1β and IL …
[HTML][HTML] Targeting of neuroinflammation by glibenclamide in Covid-19: old weapon from arsenal
GES Batiha, HM Al-Kuraishy, AI Al-Gareeb… - …, 2023 - Springer
Abstract In coronavirus disease 2019 (Covid-19) era, neuroinflammation may develop due
to neuronal tropism of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) …
to neuronal tropism of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) …
[HTML][HTML] NLRP3 inflammasome activation in COVID-19: an interlink between risk factors and disease severity
NLRP3 inflammasome is a critical immune component that plays a crucial role in mounting
innate immune responses. The deleterious effects of inflammasome activation have been …
innate immune responses. The deleterious effects of inflammasome activation have been …
[HTML][HTML] Lowered quality of life in long COVID is predicted by affective symptoms, chronic fatigue syndrome, inflammation and neuroimmunotoxic pathways
The physio-affective phenome of Long COVID-19 is predicted by (a) immune-inflammatory
biomarkers of the acute infectious phase, including peak body temperature (PBT) and …
biomarkers of the acute infectious phase, including peak body temperature (PBT) and …
[HTML][HTML] The IL-1 cytokine family as custodians of barrier immunity
Abstract The interleukin-1 (IL-1) family of cytokines and receptors are implicated in the
functioning of innate and adaptive immunity and the genesis of inflammation. They are …
functioning of innate and adaptive immunity and the genesis of inflammation. They are …
Systems analysis shows that thermodynamic physiological and pharmacological fundamentals drive COVID‐19 and response to treatment
RJ Head, ER Lumbers, B Jarrott… - Pharmacology …, 2022 - Wiley Online Library
Why a systems analysis view of this pandemic? The current pandemic has inflicted almost
unimaginable grief, sorrow, loss, and terror at a global scale. One of the great ironies with …
unimaginable grief, sorrow, loss, and terror at a global scale. One of the great ironies with …
MCC950 in the treatment of NLRP3-mediated inflammatory diseases: Latest evidence and therapeutic outcomes
S Bakhshi, S Shamsi - International Immunopharmacology, 2022 - Elsevier
Evidence suggests that various innate immune system components are involved in
pathological inflammatory conditions. Among these components, the NLR family pyrin …
pathological inflammatory conditions. Among these components, the NLR family pyrin …