The efficacy of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition has
broadened lipid-lowering therapy thus providing decreased risk in atherosclerotic …

Adrenal glands, vital for steroid secretion and the regulation of metabolism, stress responses
and immune activation, experience age-related decline, impacting systemic health …

Obesity and nonalcoholic fatty liver disease (NAFLD) are global health concerns, and thus,
drugs for the long-term treatment of these diseases are urgently needed. We previously …

The pathological feature of hypoxic pulmonary hypertension (PH) is pulmonary vascular
remodeling (PVR), primarily attributed to the hyperproliferation and apoptosis resistance of …

Hypercholesterolemia, one of the most common lipid metabolic diseases, may cause severe
complications and even death. However, the effect of hypercholesterolemia on drug …

Objective Obesity and insulin resistance greatly increase the risk of nonalcoholic fatty liver
disease and steatohepatitis (NAFLD/NASH). We have previously discovered that whole …

Dear Editor, Hypercholesterolemia is the leading risk factor for cardiovascular diseases.
Current evidence suggests that the heritability for blood cholesterol levels is high, with 40 …

This manuscript proposes an efficient and reproducible protocol for the generation of
genetically modified human induced pluripotent stem cells (hiPSCs) by genome editing …

Atherosclerosis predisposes to myriad cardiovascular complications, including myocardial
infarction and stroke. Statins have revolutionised cholesterol management but they do not …

Despite successive advancement of genome editing technology with zinc finger nucleases
(ZFNs) and transcription activator-like effector nucleases (TALENs), the recent breakthrough …