Type 3 resistant starch from Canna edulis (Ce-RS3) is an insoluble dietary fiber which could
improve blood lipids in animals, but clinically robust evidence is still lacking. We performed a …

Background Recently deorphanized G protein-coupled receptor 146 (GPR146) was shown
to respond to signal from a newly identified hormone—cholesin—and to play a role in …

Background Non-specific Orbital Inflammation (NSOI) is a chronic idiopathic condition
marked by extensive polymorphic lymphoid infiltration in the orbital area. The integration of …

The development of gene editing tools has been a significant area of research in the life
sciences for nearly 30 years. These tools have been widely utilized in disease detection and …

Familial hypercholesterolemia (FH) as a high-frequency genetic disorder is diagnosed
based on family and/or patient's history of coronary heart disease (CHD) or some other …

C-peptide is usually considered as a marker of insulin secretion and has no physiological
function. This study aimed to assess the association between serum C-peptide level as …

Here, we outline and deliberate on recent progress focused on: enhancing comprehension
of the effects of inhibiting GPR146 in humans through genetic instruments, evaluating the …

Familial hypercholesterolemia (FH), mainly arising from loss-of-function mutation of the low-
density lipoprotein receptor (LDLR), is a life-threatening inherited cardiometabolic disorder …

The fusion of villous cytotrophoblasts into the multinucleated syncytiotrophoblast is critical
for the essential functions of the mammalian placenta. Using RNA‐Seq gene expression …

In BRIef Page 1 www.nature.com/nrcardio Deficiency in the orphan G proteincoupled receptor
146 (GPR146) decreases blood lipid levels and protects against atherosclerosis in mice …