Cellular senescence and the tumour microenvironment

M Takasugi, Y Yoshida, N Ohtani - Molecular oncology, 2022 - Wiley Online Library
The senescence‐associated secretory phenotype (SASP), where senescent cells produce a
variety of secreted proteins including inflammatory cytokines, chemokines, matrix …

Aging and Inflammation

A Singh, SH Schurman… - Cold Spring …, 2024 - perspectivesinmedicine.cshlp.org
Aging can be conceptualized as the progressive disequilibrium between stochastic damage
accumulation and resilience mechanisms that continuously repair that damage, which …

Excess of body weight is associated with accelerated T-cell senescence in hospitalized COVID-19 patients

MP Madruga, LK Grun, LSMD Santos, FO Friedrich… - Immunity & …, 2024 - Springer
Background Several risk factors have been involved in the poor clinical progression of
coronavirus disease-19 (COVID-19), including ageing, and obesity. SARS-CoV-2 may …

Accelerated T-Cell immunosenescence in cytomegalovirus-seropositive individuals after severe Acute Respiratory Syndrome Coronavirus 2 infection

P Álvarez-Heredia, I Reina-Alfonso… - The Journal of …, 2023 - academic.oup.com
Cytomegalovirus (CMV) infection is a major driver of accelerated immunosenescence
related to CD28null T cell expansion. CMV infection and these proatherogenic T cells have …

Suppressed transcript diversity and immune response in COVID-19 ICU patients: a longitudinal study

P Mehta, P Chattopadhyay, R Mohite… - Life Science …, 2024 - life-science-alliance.org
Understanding the dynamic changes in gene expression during Acute Respiratory Distress
Syndrome (ARDS) progression in post-acute infection patients is crucial for unraveling the …

Machine learning of flow cytometry data reveals the delayed innate immune responses correlate with the severity of COVID-19

J Zhu, T Chen, X Mao, Y Fang, H Sun… - Frontiers in …, 2023 - frontiersin.org
Introduction The COVID-19 pandemic has posed a major burden on healthcare and
economic systems across the globe for over 3 years. Even though vaccines are available …

Distinct T cell responsiveness to different COVID-19 vaccines and cross-reactivity to SARS-CoV-2 variants with age and CMV status

J Brummelman, S Suárez-Hernández… - Frontiers in …, 2024 - frontiersin.org
Introduction Accumulating evidence indicates the importance of T cell immunity in
vaccination-induced protection against severe COVID-19 disease, especially against SARS …

Immunity in the Progeroid Model of Cockayne Syndrome: Biomarkers of Pathological Aging

K Zayoud, A Chikhaoui, I Kraoua, A Tebourbi, D Najjar… - Cells, 2024 - mdpi.com
Cockayne syndrome (CS) is a rare autosomal recessive disorder that affects the DNA repair
process. It is a progeroid syndrome predisposing patients to accelerated aging and to …

Spanish HCMV Seroprevalence in the 21st Century

P Álvarez-Heredia, I Reina-Alfonso… - Viruses, 2023 - mdpi.com
Human cytomegalovirus (HCMV) is linked to age-related diseases like cardiovascular
disease, neurodegenerative conditions, and cancer. It can also cause congenital defects …

The Influence of KE and EW Dipeptides in the Composition of the Thymalin Drug on Gene Expression and Protein Synthesis Involved in the Pathogenesis of COVID …

N Linkova, V Khavinson, A Diatlova… - International Journal of …, 2023 - mdpi.com
Thymalin is an immunomodulatory drug containing a polypeptide extract of thymus that has
demonstrated efficacy in the therapy of acute respiratory distress syndrome and chronic …