The major concept of" oxidative stress" is an excess elevated level of reactive oxygen
species (ROS) which are generated from vigorous metabolism and consumption of oxygen …

Microorganisms, including bacteria, viruses, fungi, and other eukaryotes, play critical roles in
human health. An altered microbiome can be associated with complex diseases …

The activation of the cyclic GMP-AMP synthase-stimulator of interferon gene (STING)
pathway has been associated with the pathogenesis of many autoimmune and inflammatory …

Activation of the stimulator of interferon gene (STING)-mediated innate immune response
has been suggested as a promising therapeutic strategy for cancers. However, the effects of …

Up to 30% of colorectal, endometrial and gastric cancers have a deficiency in mismatch
repair (MMR) protein expression due to either germline or epigenetic inactivation. Patients …

Cytokine storm is a common complication of COVID-19 pneumonia and has been proven to
contribute to high mortality rates. However, current treatment approaches exhibit limited …

Impaired wound healing is one of the severe complications of diabetes. Macrophages have
been shown to play a vital role in wound healing. In different wound environments …

Diffuse midline gliomas (DMG) are a highly aggressive and universally fatal subgroup of
pediatric tumors responsible for the majority of childhood brain tumor deaths. Median overall …

Aging is the primary risk factor for most neurodegenerative diseases, including Alzheimer's
disease. Major hallmarks of brain aging include neuroinflammation/immune activation and …

Misfolded protein aggregates may cause toxic proteinopathy, including autosomal dominant
tubulointerstitial kidney disease due to uromodulin mutations (ADTKD-UMOD), a leading …