MUC2 and related bacterial factors: therapeutic targets for ulcerative colitis

D Yao, W Dai, M Dong, C Dai, S Wu - EBioMedicine, 2021 - thelancet.com
Abstract The mucin2 (MUC2) mucus barrier acts as the first barrier that prevents direct
contact between intestinal bacteria and colonic epithelial cells. Bacterial factors related to …

Investigating causality with fecal microbiota transplantation in rodents: applications, recommendations and pitfalls

CE Gheorghe, NL Ritz, JA Martin, HR Wardill… - Gut …, 2021 - Taylor & Francis
In recent years, studies investigating the role of the gut microbiota in health and diseases
have increased enormously–making it essential to deepen and question the research …

Kaempferol alleviates murine experimental colitis by restoring gut microbiota and inhibiting the LPS-TLR4-NF-κB axis

Y Qu, X Li, F Xu, S Zhao, X Wu, Y Wang… - Frontiers in …, 2021 - frontiersin.org
Intestinal microbiota dysbiosis is an established characteristic of ulcerative colitis (UC).
Regulating the gut microbiota is an attractive alternative UC treatment strategy, considering …

[HTML][HTML] Optimizing therapeutic outcomes of immune checkpoint blockade by a microbial tryptophan metabolite

G Renga, E Nunzi, M Pariano, M Puccetti… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Despite the great success, the therapeutic benefits of immune checkpoint
inhibitors (ICIs) in cancer immunotherapy are limited by either various resistance …

Beneficial effects of repeated washed microbiota transplantation in children with autism

ZY Pan, HJ Zhong, DN Huang, LH Wu, XX He - Frontiers in Pediatrics, 2022 - frontiersin.org
Objective While fecal microbiota transplantation is demonstrated to improve symptoms of
autism spectrum disorder (ASD), it remains unclear whether additional treatment courses …

Fecal microbiota transplantation for diseases: Therapeutic potential, methodology, risk management in clinical practice

Z Qu, P Tian, B Yang, J Zhao, G Wang, W Chen - Life Sciences, 2022 - Elsevier
Background More than 95% of human diseases may be related to the disturbance of gut
microbes. As a treatment method that extensively regulates the gut microbes, fecal …

Polysaccharide, fecal microbiota, and curcumin-based novel oral colon-targeted solid self-nanoemulsifying delivery system: Formulation, characterization, and in-vitro …

L Corrie, M Gulati, A Awasthi, S Vishwas, J Kaur… - Materials Today …, 2022 - Elsevier
The use of polysaccharides in preparation of microbially triggered colon-targeted delivery
system has been explored extensively to deliver drugs at the colonic site. This type of …

Hesperetin ameliorates DSS-induced colitis by maintaining the epithelial barrier via blocking RIPK3/MLKL necroptosis signaling

J Zhang, H Lei, X Hu, W Dong - European Journal of Pharmacology, 2020 - Elsevier
Hesperetin, a flavonoid from citrus fruits, possess various pharmacological properties,
including anti-inflammatory, anti-oxidative, anti-tumor potentials. However, the role and its …

Electroacupuncture preserves intestinal barrier integrity through modulating the gut microbiota in DSS-induced chronic colitis

L Wang, J An, S Song, M Mei, W Li, F Ding, S Liu - Life Sciences, 2020 - Elsevier
Abstract Aims Electroacupuncture (EA) at ST36 has been verified to ameliorate experimental
acute colitis. However, the effect of EA on chronic colitis and its mechanism has not yet been …

Intestinal microbiota regulates colonic inflammation in fluorosis mice by TLR/NF-κB pathway through short-chain fatty acids

S Zhang, T Zhao, Y Wang, J Mi, J Liu, X Fan… - Food and Chemical …, 2023 - Elsevier
Intestinal inflammation and microbial dysbiosis are found simultaneously in patients with
fluorosis. However, whether the inflammation derived from fluoride exposure only or …