Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing

C Zhou, B Zhang, Y Yang, Q Jiang, T Li, J Gong… - Stem Cell Research & …, 2023 - Springer
Wound healing is a dynamic and highly sequential process involving a series of overlapping
spatial and temporal phases, including hemostasis, inflammation, proliferation, and tissue …

[HTML][HTML] Breakthrough of extracellular vesicles in pathogenesis, diagnosis and treatment of osteoarthritis

Z Liu, Y Zhuang, L Fang, C Yuan, X Wang, K Lin - Bioactive Materials, 2023 - Elsevier
Osteoarthritis (OA) is a highly prevalent whole-joint disease that causes disability and pain
and affects a patient's quality of life. However, currently, there is a lack of effective early …

Biomaterials for in situ cell therapy

C Wang, S Wang, DD Kang, Y Dong - BMEMat, 2023 - Wiley Online Library
Cell therapy has revolutionized the treatment of various diseases, such as cancers, genetic
disorders, and autoimmune diseases. Currently, most cell therapy products rely on ex vivo …

Stroke: Molecular mechanisms and therapies: Update on recent developments

F Shehjar, B Maktabi, ZA Rahman, GA Bahader… - Neurochemistry …, 2023 - Elsevier
Stroke, a neurological disease, is one of the leading causes of death worldwide, resulting in
long-term disability in most survivors. Annual stroke costs in the United States alone were …

Molecular mechanisms and clinical application of multipotent stem cells for spinal cord injury

M Szymoniuk, J Litak, L Sakwa, A Dryla, W Zezuliński… - Cells, 2022 - mdpi.com
Spinal Cord Injury (SCI) is a common neurological disorder with devastating psychical and
psychosocial sequelae. The majority of patients after SCI suffer from permanent disability …

Targeted Delivery of RGD-CD146+CD271+ Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Promotes Blood–Spinal Cord Barrier Repair after …

Y Xie, Y Sun, Y Liu, J Zhao, Q Liu, J Xu, Y Qin, R He… - ACS …, 2023 - ACS Publications
Spinal cord injury (SCI) disrupts the blood–spinal cord barrier (BSCB), potentially
exacerbating nerve damage and emphasizing the criticality of preserving the BSCB integrity …

A review of biomimetic and biodegradable magnetic scaffolds for bone tissue engineering and oncology

G Paltanea, V Manescu, I Antoniac, A Antoniac… - International Journal of …, 2023 - mdpi.com
Bone defects characterized by limited regenerative properties are considered a priority in
surgical practice, as they are associated with reduced quality of life and high costs. In bone …

Intra-articular mesenchymal stem cell injection for knee osteoarthritis: mechanisms and clinical evidence

P Wei, R Bao - International Journal of Molecular Sciences, 2022 - mdpi.com
Knee osteoarthritis presents higher incidences than other joints, with increased prevalence
during aging. It is a progressive process and may eventually lead to disability. Mesenchymal …

Advances in mesenchymal stem/stromal cell-based therapy and their extracellular vesicles for skin wound healing

MJ Saadh, AA Ramírez-Coronel, RS Saini… - Human Cell, 2023 - Springer
Wound healing is a dynamic and complicated process containing overlapping phases.
Presently, definitive therapy is not available, and the investigation into optimal wound care is …

Versatile hypoxic extracellular vesicles laden in an injectable and bioactive hydrogel for accelerated bone regeneration

J Deng, X Wang, W Zhang, L Sun, X Han… - Advanced Functional …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have emerged as
an appealing alternative to cell therapy in regenerative medicine. Unlike bone marrow …