Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although
still an evolving field with much to explore, it has rapidly gained significance by providing …

Aging is a major risk factor for numerous chronic diseases. Vaccination offers a promising
strategy to combat these age-related diseases by targeting specific antigens and inducing …

About 80% of brain disorders have a genetic basis. The pathogenesis of most
neurodegenerative diseases is associated with a myriad of genetic defects, epigenetic …

Epigenetic clocks are accurate predictors of human chronological age based on the analysis
of DNA methylation (DNAm) at specific CpG sites. However, a systematic comparison …

Owing to renal reabsorption and the loss of uricase activity, uric acid (UA) is strictly
maintained at a higher physiological level in humans than in other mammals, which …

Fatigue, an increasingly acknowledged symptom in various chronic diseases, has garnered
heightened attention, during the medical era of bio-psycho-social model. Its persistence not …

Neural stem cells play a crucial role in maintaining brain homeostasis. Neural stem cells
senescence can lead to the decline of nerve repair and regeneration, causing brain aging …

The emergence of resistance to prostate cancer (PCa) treatment, particularly to androgen
deprivation therapy (ADT), has posed a significant challenge in the field of PCa …

Impaired activity of the hypothalamic-pituitary axis and reduced blood levels of
glucocorticoids (GCs) are signature features of stress-related maladies. Recent evidence …

Time-lapse microscopy for embryos is a non-invasive technology used to characterize early
embryo development. This study employs time-lapse microscopy and machine learning to …