In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically
packaged inside the nucleus. This complex genome organization includes multiscale …

Chromatin, the template for epigenetic regulation, is a highly dynamic entity that is constantly
reshaped during early development and differentiation. Epigenetic modification of chromatin …

In mammals, translational control plays critical roles during oocyte-to-embryo transition
(OET) when transcription ceases. However, the underlying regulatory mechanisms remain …

INTRODUCTION Genomes are spatially organized across length scales from single base
pairs to whole chromosomes. This organization is thought to regulate gene expression and …

The activation of the embryonic genome marks the first major wave of transcription in the
developing organism. Zygotic genome activation (ZGA) in mouse 2-cell embryos and 8-cell …

Translational regulation plays an important role in gene expression and function. Although
the transcriptional dynamics of mouse preimplantation embryos have been well …

The molecular pathways that trigger the initiation of embryogenesis after fertilization in
flowering plants, and prevent its occurrence without fertilization, are not well understood …

Translational regulation plays a critical role during the oocyte-to-embryo transition (OET)
and zygotic genome activation (ZGA). Here, we integrated ultra-low-input ribosome profiling …

A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

CRISPR-Cas9 technology provides a powerful system for genome engineering. However,
variable activity across different single guide RNAs (sgRNAs) remains a significant …