Schizophrenia is a debilitating psychiatric disorder that affects millions of people worldwide;
however, its etiology is poorly understood at the molecular and neurobiological levels. A …

There has been substantial progress in understanding the genetics of schizophrenia over
the past 15 years. This has revealed a highly polygenic condition with the majority of the …

Methods integrating genetics with transcriptomic reference panels prioritize risk genes and
mechanisms at only a fraction of trait-associated genetic loci, due in part to an overreliance …

Tandem repeats (TRs) are prevalent throughout the genome, constituting at least 3% of the
genome, and often highly polymorphic. The high mutation rate of TRs, which can be orders …

With new data about different aspects of schizophrenia being continually generated, it
becomes necessary to periodically revisit exactly what we know. Along with a need to review …

Objective SETD1A encodes a histone methyltransferase involved in various cell cycle
regulatory processes. Loss-of-function SETD1A variants have been associated with …

Previous studies have shown mitochondrial dysfunction in schizophrenia (SZ) patients,
which may be caused by mitochondrial DNA (mtDNA) alterations. However, there are few …

Background Schizophrenia (SCZ) is a severe neuropsychiatric disorder of complex, poorly
understood etiology, associated with both genetic and environmental factors. De novo …

Schizophrenia symptomatology includes negative symptoms and cognitive impairment.
Several studies have linked schizophrenia with the PDE4 family of enzymes due to their …

Psychosis is a severe mental disorder characterized by abnormal thoughts and perceptions
(eg, hallucinations) occurring quintessentially in schizophrenia and in several other …