S Latini, F Pedata - Journal of neurochemistry, 2001 - Wiley Online Library
Adenosine has several functions within the CNS that involve an inhibitory tone of neurotransmission and neuroprotective actions in pathological conditions. The …
By general consensus, the omnipresent purine nucleoside adenosine is considered a major regulator of local tissue function, especially when energy supply fails to meet cellular energy …
JM Lee, MC Grabb, GJ Zipfel… - The Journal of clinical …, 2000 - Am Soc Clin Investig
Tissue responses to ischemia influx into neurons. The gating of glutamate receptor– activated channels effectively achieves membrane shunting, which spreads in waves …
RA Cunha - Neurochemistry international, 2001 - Elsevier
Adenosine exerts two parallel modulatory roles in the CNS, acting as a homeostatic modulator and also as a neuromodulator at the synaptic level. We will present evidence to …
Adenosine is a neuromodulator that operates via the most abundant inhibitory adenosine A 1 receptors (A 1 Rs) and the less abundant, but widespread, facilitatory A 2A Rs. It is …
This review addresses three principal questions about adenosine and sleep–wake regulation:(1) Is adenosine an endogenous sleep factor?(2) Are there specific brain regions …
There is an urgent need to develop new therapeutic approaches for the treatment of severe neurological trauma, such as stroke and spinal cord injuries. However, many drugs with …
J Zhang, A Malik, HB Choi, RWY Ko, L Dissing-Olesen… - Neuron, 2014 - cell.com
Summary Complement receptor 3 (CR3) activation in microglia is involved in neuroinflammation-related brain disorders and pruning of neuronal synapses. Hypoxia …
Adenosine is a ubiquitous homeostatic substance released from most cells, including neurones and glia. Once in the extracellular space, adenosine modifies cell functioning by …