Understanding paraxial mesoderm development and sclerotome specification for skeletal repair
Pluripotent stem cells (PSCs) are attractive regenerative therapy tools for skeletal tissues.
However, a deep understanding of skeletal development is required in order to model this …
However, a deep understanding of skeletal development is required in order to model this …
Kidney organoids: accurate models or fortunate accidents
MH Little, AN Combes - Genes & Development, 2019 - genesdev.cshlp.org
There are now many reports of human kidney organoids generated via the directed
differentiation of human pluripotent stem cells (PSCs) based on an existing understanding of …
differentiation of human pluripotent stem cells (PSCs) based on an existing understanding of …
A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery
Human pluripotent stem-cell-derived organoids are models for human development and
disease. We report a modified human kidney organoid system that generates thousands of …
disease. We report a modified human kidney organoid system that generates thousands of …
[HTML][HTML] Single-cell profiling reveals sex, lineage, and regional diversity in the mouse kidney
Chronic kidney disease affects 10% of the population with notable differences in ethnic and
sex-related susceptibility to kidney injury and disease. Kidney dysfunction leads to …
sex-related susceptibility to kidney injury and disease. Kidney dysfunction leads to …
Spatial dynamic metabolomics identifies metabolic cell fate trajectories in human kidney differentiation
Accumulating evidence demonstrates important roles for metabolism in cell fate
determination. However, it is a challenge to assess metabolism at a spatial resolution that …
determination. However, it is a challenge to assess metabolism at a spatial resolution that …
Generation of human PSC-derived kidney organoids with patterned nephron segments and a de novo vascular network
Human pluripotent stem cell-derived kidney organoids recapitulate developmental
processes and tissue architecture, but intrinsic limitations, such as lack of vasculature and …
processes and tissue architecture, but intrinsic limitations, such as lack of vasculature and …
Generation of model tissues with dendritic vascular networks via sacrificial laser-sintered carbohydrate templates
IS Kinstlinger, SH Saxton, GA Calderon… - Nature biomedical …, 2020 - nature.com
Sacrificial templates for patterning perfusable vascular networks in engineered tissues have
been constrained in architectural complexity, owing to the limitations of extrusion-based 3D …
been constrained in architectural complexity, owing to the limitations of extrusion-based 3D …
3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening
The podocytes within the glomeruli of the kidney maintain the filtration barrier by forming
interdigitating foot processes with intervening slit diaphragms, disruption in which results in …
interdigitating foot processes with intervening slit diaphragms, disruption in which results in …
A simple bioreactor-based method to generate kidney organoids from pluripotent stem cells
Kidney organoids made from pluripotent stem cells have the potential to revolutionize how
kidney development, disease, and injury are studied. Current protocols are technically …
kidney development, disease, and injury are studied. Current protocols are technically …
Progressive recruitment of mesenchymal progenitors reveals a time-dependent process of cell fate acquisition in mouse and human nephrogenesis
Mammalian nephrons arise from a limited nephron progenitor pool through a reiterative
inductive process extending over days (mouse) or weeks (human) of kidney development …
inductive process extending over days (mouse) or weeks (human) of kidney development …