Development of an Entirely Cloned cDNA-Based Reverse Genetics System for Tofla Virus of Orthonairovirus

S Wulandari, S Nyampong, SMW Lokupathirage… - Virology, 2024 - Elsevier
The genus Orthonairovirus includes highly pathogenic tick-borne viruses such as the
Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV). A reverse genetics system is …

Crimean-Congo hemorrhagic fever virus nucleocapsid protein has dual RNA binding modes

S Jeeva, S Pador, B Voss, SS Ganaie, MA Mir - PLoS One, 2017 - journals.plos.org
Crimean Congo hemorrhagic fever, a zoonotic viral disease, has high mortality rate in
humans. There is currently no vaccine for Crimean Congo hemorrhagic fever virus (CCHFV) …

Mapping of the interaction domains of the Crimean–Congo hemorrhagic fever virus nucleocapsid protein

JML Macleod, H Marmor… - Journal of General …, 2015 - microbiologyresearch.org
Crimean–Congo hemorrhagic fever virus (CCHFV) is a member of the genus Nairovirus of
the family Bunyaviridae, that can cause severe haemorrhagic fever in humans, with mortality …

Vaccine approaches and treatment aspects against Crimean Congo hemorrhagic fever

S Sarmadi, A Ghalyanchilangeroudi, H Najafi - VirusDisease, 2024 - Springer
Crimean-Congo hemorrhagic fever [CCHF] is a severe infectious viral disease caused by a
tick borne virus which can lead to fatal hemorrhagic disease in humans. It has been reported …

Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of …

B Álvarez-Rodríguez, C Tiede, ACR Hoste… - PLoS Neglected …, 2020 - journals.plos.org
Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) is one of the most widespread
medically important arboviruses, causing human infections that result in mortality rates of up …

Regulation of Hazara virus growth through apoptosis inhibition by viral nucleoprotein

Y Matsumoto, T Nouchi, K Ohta, M Nishio - Archives of virology, 2019 - Springer
Hazara virus (HAZV) is closely related to Crimean-Congo hemorrhagic fever virus (CCHFV),
but differs in that it is non-pathogenic to humans. Since HAZV was isolated for the first time in …

The nairovirus nairobi sheep disease virus/ganjam virus induces the translocation of protein disulphide isomerase-like oxidoreductases from the endoplasmic …

L Lasecka, MD Baron - PloS one, 2014 - journals.plos.org
Nairobi sheep disease virus (NSDV) of the genus Nairovirus causes a haemorrhagic
gastroenteritis in sheep and goats with mortality up to 90%; the virus is found in East and …

Analysis of highly frequent point mutations in glycoprotein C, glycoprotein N, and nucleoprotein of CCHFV

N Kaushal, M Baranwal - Biotechnology and Applied …, 2024 - Wiley Online Library
Crimean‐Congo hemorrhagic fever virus (CCHFV) is classified among top 10 priority
pathogens by World Health Organization. CCHFV belongs to Bunyaviridae family and …

Complementary mutations in the N and L proteins for restoration of viral RNA synthesis

W Li, RH Gumpper, Y Uddin, I Schmidt-Krey… - Journal of …, 2018 - Am Soc Microbiol
During viral RNA synthesis by the viral RNA-dependent RNA polymerase (vRdRp) of
vesicular stomatitis virus, the sequestered RNA genome must be released from the …

Hazara orthonairovirus nucleoprotein facilitates viral cell-to-cell spread by modulating tight junction protein, claudin-1

K Ohta, N Saka, M Fukasawa, M Nishio - Frontiers in Microbiology, 2023 - frontiersin.org
Background Tight junctions act as a barrier that prevents invasion of pathogens through
epithelial cells. This study aims to elucidate the correlation between tight junctions and …