The impact of obesity: a narrative review

BCC Lam, AYL Lim, SL Chan, MPS Yum… - Singapore medical …, 2023 - journals.lww.com
Obesity is a disease with a major negative impact on human health. However, people with
obesity may not perceive their weight to be a significant problem and less than half of …

Learning from the nexus of autoimmunity and cancer

D Mangani, D Yang, AC Anderson - Immunity, 2023 - cell.com
The immune system plays critical roles in both autoimmunity and cancer, diseases at
opposite ends of the immune spectrum. Autoimmunity arises from loss of T cell tolerance …

Type 2 diabetes: how much of an autoimmune disease?

P De Candia, F Prattichizzo, S Garavelli… - Frontiers in …, 2019 - frontiersin.org
Type 2 diabetes (T2D) is characterized by a progressive status of chronic, low-grade
inflammation (LGI) that accompanies the whole trajectory of the disease, from its inception to …

Jejunal T cell inflammation in human obesity correlates with decreased enterocyte insulin signaling

M Monteiro-Sepulveda, S Touch, C Mendes-Sá… - Cell metabolism, 2015 - cell.com
In obesity, insulin resistance is linked to inflammation in several tissues. Although the gut is
a very large lymphoid tissue, inflammation in the absorptive small intestine, the jejunum …

Multiple sclerosis and obesity: The role of adipokines

J Correale, M Marrodan - Frontiers in immunology, 2022 - frontiersin.org
Multiple Sclerosis (MS), a chronic inflammatory disease of the central nervous system that
leads to demyelination and neurodegeneration has been associated with various …

[HTML][HTML] Obesity and novel management of inflammatory bowel disease

JH Kim, CM Oh, JH Yoo - World Journal of Gastroenterology, 2023 - ncbi.nlm.nih.gov
Obesity is prevalent within the inflammatory bowel disease (IBD) population, particularly in
newly developed countries. Several epidemiological studies have suggested that 15%-40 …

Sex differences in tolerability to anti‐programmed cell death protein 1 therapy in patients with metastatic melanoma and non‐small cell lung cancer: are we all equal?

N Duma, A Abdel‐Ghani, S Yadav, KP Hoversten… - The …, 2019 - academic.oup.com
Background Immune‐related adverse events (irAEs) have emerged as a serious clinical
issue in the use of immune checkpoint inhibitors (ICIs). Risk factors for irAEs remain …

[HTML][HTML] Emerging roles of adipose tissue in the pathogenesis of psoriasis and atopic dermatitis in obesity

Z Guo, Y Yang, Y Liao, Y Shi, L Zhang - JID Innovations, 2022 - Elsevier
Obesity is a growing epidemic worldwide, and it is also considered a major environmental
factor contributing to the pathogenesis of inflammatory skin diseases, including psoriasis …

Mendelian randomization as a tool to gain insights into the mosaic causes of autoimmune diseases

C Chen, P Wang, RD Zhang, Y Fang, LQ Jiang… - Autoimmunity …, 2022 - Elsevier
Autoimmune diseases (ADs) are a broad range of disorders which are characterized by long-
term inflammation and tissue damage arising from an immune response against one's own …

Biological activities underlying the therapeutic effect of quercetin on inflammatory bowel disease

YL Lyu, HF Zhou, J Yang, FX Wang… - Mediators of …, 2022 - Wiley Online Library
Inflammatory bowel disease (IBD) is a chronic autoimmune disorder stemming from
unrestrained immune activation and subsequent destruction of colon tissue. Genetic …