High BMI and the risk for incident type 1 Diabetes Mellitus: a systematic review and meta-analysis of aggregated cohort studies

M Nitecki, HC Gerstein, Y Balmakov, E Tsur… - Cardiovascular …, 2023 - Springer
Background There is uncertainty regarding the role of obesity in type 1 diabetes
development. The aim of this systematic review and meta-analysis was to collect and …

Obesity and the risk of Multiple Sclerosis. The role of Leptin

M Marrodan, MF Farez… - Annals of Clinical …, 2021 - Wiley Online Library
Objective To investigate the effects of leptin on different T‐cell populations, in order to gain
more insight into the link between leptin and obesity. Methods Three hundred and nine …

Pathogenic role of adipose tissue-derived mesenchymal stem cells in obesity and obesity-related inflammatory diseases

J Pestel, F Blangero, A Eljaafari - Cells, 2023 - mdpi.com
Adipose tissue-derived mesenchymal stem cells (ASCs) are adult stem cells, endowed with
self-renewal, multipotent capacities, and immunomodulatory properties, as mesenchymal …

Impact of obesity on the course of management of inflammatory bowel disease—a review

A Michalak, B Kasztelan-Szczerbińska, H Cichoż-Lach - Nutrients, 2022 - mdpi.com
It is already well-known that visceral adipose tissue is inseparably related to the
pathogenesis, activity, and general outcome of inflammatory bowel disease (IBD). We are …

Pediatric obesity and the immune system

GR Umano, C Pistone, E Tondina, A Moiraghi… - Frontiers in …, 2019 - frontiersin.org
Obesity has reached pandemic proportion and represents a major risk for several
comorbidities. In addition to metabolic and cardiovascular obesity-related diseases, recent …

Etiology and pathogenesis of psoriatic arthritis

JL Barnas, CT Ritchlin - Rheumatic Disease Clinics, 2015 - rheumatic.theclinics.com
Arthritis associated with psoriasis was first described in 1956 by Wright. 1 It was not until
1973, however, that Moll and Wright 2 defined the various clinical phenotypes, including …

Towards prevention of autoantibody-positive rheumatoid arthritis: from lifestyle modification to preventive treatment

DM Gerlag, JM Norris, PP Tak - Rheumatology, 2016 - academic.oup.com
Recent advances in research into the earliest phases of RA have provided additional
insights into the processes leading from the healthy to the diseased state. These insights …

An adverse lipid profile and increased levels of adiposity significantly predict clinical course after a first demyelinating event

P Tettey, S Simpson, B Taylor, AL Ponsonby… - Journal of Neurology …, 2017 - jnnp.bmj.com
Objective To investigate the prospective associations between adiposity and lipid-related
variables and conversion to multiple sclerosis (MS), time to subsequent relapse and …

Crosstalk between skin inflammation and adipose tissue-derived products: pathogenic evidence linking psoriasis to increased adiposity

A Chiricozzi, A Raimondo, S Lembo… - Expert Review of …, 2016 - Taylor & Francis
Introduction: Psoriasis is a chronic skin disorder associated with several comorbid
conditions. In psoriasis pathogenesis, the role of some cytokines, including TNF-α and IL-17 …

Obesity is common in axial spondyloarthritis and is associated with poor clinical outcome

F Maas, S Arends, E van der Veer, F Wink… - The Journal of …, 2016 - jrheum.org
Objective. To assess the prevalence of overweight and obesity in a large cohort of patients
with axial spondyloarthritis (axSpA) in comparison with the general population. To explore …