Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy

Q Zhang, R Xiang, S Huo, Y Zhou, S Jiang… - Signal transduction and …, 2021 - nature.com
The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in an unprecedented setback …

COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection

S Beyerstedt, EB Casaro, ÉB Rangel - European journal of clinical …, 2021 - Springer
COVID-19 pandemic is caused by the novel coronavirus SARS-CoV-2. Angiotensin-
converting enzyme 2 (ACE2) is not only an enzyme but also a functional receptor on cell …

SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex

D Mannar, JW Saville, X Zhu, SS Srivastava… - Science, 2022 - science.org
The newly reported Omicron variant is poised to replace Delta as the most prevalent severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant across the world. Cryo …

Neutralizing antibodies for the prevention and treatment of COVID-19

L Du, Y Yang, X Zhang - Cellular & molecular immunology, 2021 - nature.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) initiates the infection
process by binding to the viral cellular receptor angiotensin-converting enzyme 2 through …

SARS-CoV-2 antiviral therapy

K Tao, PL Tzou, J Nouhin, H Bonilla… - Clinical microbiology …, 2021 - Am Soc Microbiol
The development of effective antiviral therapy for COVID-19 is critical for those awaiting
vaccination, as well as for those who do not respond robustly to vaccination. This review …

[PDF][PDF] Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy

I Ullah, J Prévost, MS Ladinsky, H Stone, M Lu… - Immunity, 2021 - cell.com
Neutralizing antibodies (NAbs) are effective in treating COVID-19, but the mechanism of
immune protection is not fully understood. Here, we applied live bioluminescence imaging …

Antibody-dependent cellular cytotoxicity response to SARS-CoV-2 in COVID-19 patients

Y Yu, M Wang, X Zhang, S Li, Q Lu, H Zeng… - Signal transduction and …, 2021 - nature.com
Antibody-dependent cellular cytotoxicity (ADCC) responses to viral infection are a form of
antibody regulated immune responses mediated through the Fc fragment. Whether severe …

SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization

D Mannar, JW Saville, Z Sun, X Zhu, MM Marti… - Nature …, 2022 - nature.com
Mutations in the spike glycoproteins of SARS-CoV-2 variants of concern have independently
been shown to enhance aspects of spike protein fitness. Here, we describe an antibody …

Recent advances in novel lateral flow technologies for detection of COVID-19

WWW Hsiao, TN Le, DM Pham, HH Ko, HC Chang… - Biosensors, 2021 - mdpi.com
The development of reliable and robust diagnostic tests is one of the most efficient methods
to limit the spread of coronavirus disease 2019 (COVID-19), which is caused by the severe …

Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies

X Zhu, D Mannar, SS Srivastava, AM Berezuk… - PLoS …, 2021 - journals.plos.org
The recently reported “UK variant”(B. 1.1. 7) of SARS-CoV-2 is thought to be more infectious
than previously circulating strains as a result of several changes, including the N501Y …