Distant residues modulate conformational opening in SARS-CoV-2 spike protein
D Ray, L Le, I Andricioaei - Proceedings of the National …, 2021 - National Acad Sciences
Infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) involves the
attachment of the receptor-binding domain (RBD) of its spike proteins to the ACE2 receptors …
attachment of the receptor-binding domain (RBD) of its spike proteins to the ACE2 receptors …
Co-infection of SARS-CoV-2 and influenza virus causes more severe and prolonged pneumonia in hamsters
T Kinoshita, K Watanabe, Y Sakurai, K Nishi… - Scientific reports, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is currently a serious public health concern …
syndrome coronavirus 2 (SARS-CoV-2) is currently a serious public health concern …
Passive immunotherapy against SARS-CoV-2: from plasma-based therapy to single potent antibodies in the race to stay ahead of the variants
The COVID-19 pandemic is now approaching 2 years old, with more than 440 million people
infected and nearly six million dead worldwide, making it the most significant pandemic …
infected and nearly six million dead worldwide, making it the most significant pandemic …
Keep out! SARS-CoV-2 entry inhibitors: their role and utility as COVID-19 therapeutics
L Chitsike, P Duerksen-Hughes - Virology Journal, 2021 - Springer
The COVID-19 pandemic has put healthcare infrastructures and our social and economic
lives under unprecedented strain. Effective solutions are needed to end the pandemic while …
lives under unprecedented strain. Effective solutions are needed to end the pandemic while …
Parallel profiling of antigenicity alteration and immune escape of SARS-CoV-2 Omicron and other variants
SARS-CoV-2 variants have evolved a variety of critical mutations, leading to antigenicity
changes and immune escape. The recent emerging SARS-CoV-2 Omicron variant attracted …
changes and immune escape. The recent emerging SARS-CoV-2 Omicron variant attracted …
A pandemic-enabled comparison of discovery platforms demonstrates a naïve antibody library can match the best immune-sourced antibodies
As a result of the SARS-CoV-2 pandemic numerous scientific groups have generated
antibodies against a single target: the CoV-2 spike antigen. This has provided an …
antibodies against a single target: the CoV-2 spike antigen. This has provided an …
SARS-CoV-2 neutralizing human antibodies protect against lower respiratory tract disease in a hamster model
Effective clinical intervention strategies for coronavirus disease 2019 (COVID-19) are
urgently needed. Although several clinical trials have evaluated use of convalescent plasma …
urgently needed. Although several clinical trials have evaluated use of convalescent plasma …
Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants
JW Saville, D Mannar, X Zhu, SS Srivastava… - Nature …, 2022 - nature.com
Abstract The Delta and Kappa variants of SARS-CoV-2 co-emerged in India in late 2020,
with the Delta variant underlying the resurgence of COVID-19, even in countries with high …
with the Delta variant underlying the resurgence of COVID-19, even in countries with high …
Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries
Y Pan, J Du, J Liu, H Wu, F Gui, N Zhang, X Deng… - Cell Discovery, 2021 - nature.com
As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to
threaten public health worldwide, the development of effective interventions is urgently …
threaten public health worldwide, the development of effective interventions is urgently …