Despite the availability of renal replacement therapy, acute kidney injury (AKI) is associated
with high mortality and morbidity. In humans, it is difficult to determine whether AKI is a …

Acute kidney injury (AKI) is a common complication in hospitalized patients, associated
with> 50% mortality in those in intensive care who require renal replacement therapy. Data …

Although neurologic sequelae of acute kidney injury (AKI) are well described, the
pathogenesis of acute uremic encephalopathy is poorly understood. This study examined …

Background—Contrast-induced acute kidney injury (CI-AKI), defined as a serum creatinine
increase≥ 0.5 mg/dL or≥ 25% within 72 hours after contrast exposure, is a common …

Background The term “cardiorenal syndrome” has generally been reserved for declining
renal function in the setting of advanced congestive heart failure. Considering the complex …

Aging kidneys undergo structural and functional changes that decrease autoregulatory
capacity and increase susceptibility to acute injury. Acute kidney injury associates with …

Renal ischemia-reperfusion (IR) contributes to the development of ischemic acute renal
failure (ARF). Multi-factorial processes are involved in the development and progression of …

Urinary biomarkers of AKI provide prognostic value for in-hospital outcomes, but little is
known about their association with longer-term mortality after surgery. We sought to assess …

Abstract Ischemia-reperfusion (I/R) injury of the kidney is a major cause of AKI. MicroRNAs
(miRs) are powerful regulators of various diseases. We investigated the role of apoptosis …

Recent studies have documented that remote organs are affected by ischemic injury to the
kidney. Here we studied whether the liver also suffers damage during induction of renal …