G protein-coupled dopamine receptors (D1, D2, D3, D4, and D5) mediate all of the
physiological functions of the catecholaminergic neurotransmitter dopamine, ranging from …

Despite a lack of recent progress in the treatment of schizophrenia, our understanding of its
genetic and environmental causes has considerably improved, and their relationship to …

The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified and
studied in the regulation of glycogen synthesis. GSK-3 functions in a wide range of cellular …

Dopamine (DA) and glutamate neurotransmission are strongly implicated in schizophrenia
pathophysiology. While most studies focus on contributions of neurons that release only DA …

For the past 50 years, the clinical efficacy of antipsychotic medications has relied on
blockade of dopamine D2 receptors. Drug development of non-D2 compounds, seeking to …

Schizophrenia is a disabling mental illness that is now recognized as a neurodevelopmental
disorder. It is likely that genetic risk factors interact with environmental perturbations to affect …

Neurotransmitters and neuromodulators, such as dopamine, participate in a wide range of
behavioral and cognitive functions in the adult brain, including movement, cognition, and …

With the ongoing consideration of the diagnostic criteria for mental disorders that is active in
the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) and International …

Mental illnesses, such as bipolar disorder, attention-deficit/hyperactivity disorder, depression
and schizophrenia are a major public health concern worldwide. Several pharmacologic …

When considering neurodevelopmental disorders (NDDs), Schizophrenia (SZ) and Autism
Spectrum Disorder (ASD) are considered to be among the most severe in term of …