Therapeutic potential of resveratrol: the in vivo evidence

JA Baur, DA Sinclair - Nature reviews Drug discovery, 2006 - nature.com
Resveratrol, a constituent of red wine, has long been suspected to have cardioprotective
effects. Interest in this compound has been renewed in recent years, first from its …

Resveratrol as an anti‐inflammatory and anti‐aging agent: Mechanisms and clinical implications

C Alarcon De La Lastra… - Molecular nutrition & food …, 2005 - Wiley Online Library
Resveratrol is a phytoalexin polyphenolic compound found in various plants, including
grapes, berries, and peanuts. Multiple lines of compelling evidence indicate its beneficial …

Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses

SS Leonard, C Xia, BH Jiang, B Stinefelt… - Biochemical and …, 2003 - Elsevier
Scavenging or quenching of the reactive oxygen species (ROS) involved in oxidative stress
has been the subject of many recent studies. Resveratrol, found in various natural food …

Are sirtuins viable targets for improving healthspan and lifespan?

JA Baur, Z Ungvari, RK Minor, DG Le Couteur… - Nature reviews Drug …, 2012 - nature.com
Although the increased lifespan of our populations illustrates the success of modern
medicine, the risk of developing many diseases increases exponentially with old age …

Cardiovascular protective effects of resveratrol

S Bradamante, L Barenghi… - Cardiovascular drug …, 2004 - Wiley Online Library
ABSTRACT Resveratrol (3, 4′, 5‐trihydroxy‐trans‐stilbene), a phytoalexin found in grape
skins, peanuts, and red wine, has been reported to have a wide range of biological and …

Anti-inflammatory responses of resveratrol

S Das, DK Das - Inflammation & Allergy-Drug Targets (Formerly …, 2007 - ingentaconnect.com
Resveratrol (trans-3, 4', 5-trihydroxystilbene), a natural polyphenolic, non-flavonoid
antioxidant, is a phytoalexin found in many plants including grapes, nuts and berries. Recent …

Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation

G Bureau, F Longpré… - Journal of neuroscience …, 2008 - Wiley Online Library
Parkinson's disease (PD) is a movement disorder characterized by a progressive loss of
nigrostriatal dopaminergic neurons. Microglia activation and neuroinflammation have been …

Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy

M Sulaiman, MJ Matta… - American Journal …, 2010 - journals.physiology.org
Reduced sarcoplasmic calcium ATPase (SERCA2a) expression has been shown to play a
significant role in the cardiac dysfunction in diabetic cardiomyopathy. The mechanism of …

Resveratrol addiction: to die or not to die

M Shakibaei, KB Harikumar… - Molecular nutrition & …, 2009 - Wiley Online Library
Resveratrol, a polyphenol derived from red grapes, berries, and peanuts, has been shown to
mediate death of a wide variety of cells. The mechanisms by which resveratrol mediates cell …

[HTML][HTML] Randomized double-blind placebo-controlled proof-of-concept trial of resveratrol for outpatient treatment of mild coronavirus disease (COVID-19)

MR McCreary, PM Schnell, DA Rhoda - Scientific Reports, 2022 - nature.com
Resveratrol is a polyphenol that has been well studied and has demonstrated anti-viral and
anti-inflammatory properties that might mitigate the effects of COVID-19. Outpatients (N …