Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

H Yu, L Lin, Z Zhang, H Zhang, H Hu - Signal transduction and targeted …, 2020 - nature.com
NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

NF‐κB signaling in inflammation and cancer

T Zhang, C Ma, Z Zhang, H Zhang, H Hu - MedComm, 2021 - Wiley Online Library
Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered
in 1986, extraordinary efforts have been made to understand the function and regulating …

Corneal stromal repair and regeneration

RR Mohan, D Kempuraj, S D'Souza, A Ghosh - Progress in retinal and eye …, 2022 - Elsevier
The cornea is a specialized, transparent, avascular, immune-privileged, and heavily
innervated tissue that affords 2/3rd of refraction to the eye. Ocular injuries, infections, and …

The role of TH17 cells in multiple sclerosis: Therapeutic implications

T Moser, K Akgün, U Proschmann, J Sellner… - Autoimmunity …, 2020 - Elsevier
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) where immunopathology is thought to be mediated by myelin-reactive CD4+ T …

The role of the adaptive immune system and T cell dysfunction in neurodegenerative diseases

A DeMaio, S Mehrotra, K Sambamurti… - Journal of …, 2022 - Springer
The adaptive immune system and associated inflammation are vital in surveillance and host
protection against internal and external threats, but can secondarily damage host tissues …

The role of Th17 response in COVID-19

D Martonik, A Parfieniuk-Kowerda, M Rogalska… - Cells, 2021 - mdpi.com
COVID-19 is an acute infectious disease of the respiratory system caused by infection with
the SARS-CoV-2 virus (Severe Acute Respiratory Syndrome Coronavirus 2). Transmission …

Exploring the Role of Staphylococcus aureus in Inflammatory Diseases

H Chen, J Zhang, Y He, Z Lv, Z Liang, J Chen, P Li… - Toxins, 2022 - mdpi.com
Staphylococcus aureus is a very common Gram-positive bacterium, and S. aureus infections
play an extremely important role in a variety of diseases. This paper describes the types of …

[HTML][HTML] Parthenolide ameliorates colon inflammation through regulating Treg/Th17 balance in a gut microbiota-dependent manner

YJ Liu, B Tang, FC Wang, L Tang, YY Lei, Y Luo… - Theranostics, 2020 - ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD) is a global health problem in which gut microbiota
dysbiosis plays an important pathogenic role. However, the current drugs for IBD treatment …

Novel therapies emerging in oncology to target the TGF-β pathway

BG Kim, E Malek, SH Choi, JJ Ignatz-Hoover… - Journal of hematology & …, 2021 - Springer
The TGF-β signaling pathway governs key cellular processes under physiologic conditions
and is deregulated in many pathologies, including cancer. TGF-β is a multifunctional …

COVID‐19 and Treg/Th17 imbalance: potential relationship to pregnancy outcomes

KP Muyayalo, DH Huang, SJ Zhao, T Xie… - American Journal of …, 2020 - Wiley Online Library
Caused by a novel type of virus, severe acute respiratory syndrome coronavirus 2 (SARS‐
CoV‐2), coronavirus disease 2019 (COVID‐19) constitutes a global public health …