Meta-analysis is pervasively used to combine multiple genome-wide association studies
(GWASs). Fine-mapping of meta-analysis studies is typically performed as in a single-cohort …

Underrepresented populations are often excluded from genomic studies due in part to a lack
of resources supporting their analyses. The 1000 Genomes Project (1kGP) and Human …

Biobanks of linked clinical patient histories and biological samples are an efficient strategy
to generate large cohorts for modern genetics research. Biobank recruitment varies by …

Interindividual variability in genes encoding drug-metabolizing enzymes, transporters,
receptors, and human leukocyte antigens has a major impact on a patient's response to …

Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-
related problems assessed with a questionnaire, is a leading cause of death and morbidity …

Polygenic risk scores (PRSs) have been widely explored in precision medicine. However,
few studies have thoroughly investigated their best practices in global populations across …

To facilitate scientific collaboration on polygenic risk scores (PRSs) research, we created an
extensive PRS online repository for 35 common cancer traits integrating freely available …

Linkage disequilibrium (LD) is the correlation among nearby genetic variants. In genetic
association studies, LD is often modeled using large correlation matrices, but this approach …

Polygenic risk scores (PRS) calculated from genome-wide association studies (GWAS) of
Europeans are known to have substantially reduced predictive accuracy in non-European …

Summary The China Kadoorie Biobank (CKB) is a population-based prospective cohort of>
512,000 adults recruited from 2004 to 2008 from 10 geographically diverse regions across …