Addressing the challenge of biomedical data inequality: An artificial intelligence perspective
Artificial intelligence (AI) and other data-driven technologies hold great promise to transform
healthcare and confer the predictive power essential to precision medicine. However, the …
healthcare and confer the predictive power essential to precision medicine. However, the …
[PDF][PDF] Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases
Proteome-wide Mendelian randomization (MR) shows value in prioritizing drug targets in
Europeans but with limited evidence in other ancestries. Here, we present a multi-ancestry …
Europeans but with limited evidence in other ancestries. Here, we present a multi-ancestry …
[HTML][HTML] The associations between gut microbiota and chronic respiratory diseases: a Mendelian randomization study
H Shi, T Zhao, RH Geng, L Sun, H Fan - Frontiers in Microbiology, 2023 - frontiersin.org
Introduction Growing evidence indicates that variations in the composition of the gut
microbiota are linked to the onset and progression of chronic respiratory diseases (CRDs) …
microbiota are linked to the onset and progression of chronic respiratory diseases (CRDs) …
[HTML][HTML] Systems genetics approaches for understanding complex traits with relevance for human disease
Quantitative traits are often complex because of the contribution of many loci, with further
complexity added by environmental factors. In medical research, systems genetics is a …
complexity added by environmental factors. In medical research, systems genetics is a …
Targeting underrepresented populations in precision medicine: A federated transfer learning approach
Targeting underrepresented populations in precision medicine: A federated transfer learning
approach Page 1 The Annals of Applied Statistics 2023, Vol. 17, No. 4, 2970–2992 …
approach Page 1 The Annals of Applied Statistics 2023, Vol. 17, No. 4, 2970–2992 …
[HTML][HTML] Demonstrating paths for unlocking the value of cloud genomics through cross cohort analysis
Recently, large scale genomic projects such as All of Us and the UK Biobank have
introduced a new research paradigm where data are stored centrally in cloud-based Trusted …
introduced a new research paradigm where data are stored centrally in cloud-based Trusted …
[HTML][HTML] Dissecting the causal effect between gut microbiota, DHA, and urate metabolism: a large-scale bidirectional Mendelian randomization
Objectives Our aim was to investigate the interactive causal effects between gut microbiota
and host urate metabolism and explore the underlying mechanism using genetic methods …
and host urate metabolism and explore the underlying mechanism using genetic methods …
A polygenic risk score for idiopathic pulmonary fibrosis and interstitial lung abnormalities
Rationale: In addition to rare genetic variants and the MUC5B locus, common genetic
variants contribute to idiopathic pulmonary fibrosis (IPF) risk. The predictive power of …
variants contribute to idiopathic pulmonary fibrosis (IPF) risk. The predictive power of …
[PDF][PDF] The UCLA ATLAS Community Health Initiative: promoting precision health research in a diverse biobank
Summary The UCLA ATLAS Community Health Initiative (ATLAS) has an initial target to
recruit 150,000 participants from across the UCLA Health system with the goal of creating a …
recruit 150,000 participants from across the UCLA Health system with the goal of creating a …
[PDF][PDF] A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma
SS Verma, HV Gudiseva, VRM Chavali, RJ Salowe… - Cell, 2024 - cell.com
Primary open-angle glaucoma (POAG), the leading cause of irreversible blindness
worldwide, disproportionately affects individuals of African ancestry. We conducted a …
worldwide, disproportionately affects individuals of African ancestry. We conducted a …