Cross-ancestry investigation of venous thromboembolism genomic predictors
Background: Venous thromboembolism (VTE) is a life-threatening vascular event with
environmental and genetic determinants. Recent VTE genome-wide association studies …
environmental and genetic determinants. Recent VTE genome-wide association studies …
Ten challenges for clinical translation in psychiatric genetics
Genome-wide association studies have identified hundreds of robust genetic associations
underlying psychiatric disorders and provided important biological insights into disease …
underlying psychiatric disorders and provided important biological insights into disease …
[PDF][PDF] Taiwan Biobank: A rich biomedical research database of the Taiwanese population
Summary The Taiwan Biobank (TWB) is an ongoing prospective study of> 150,000
individuals aged 20–70 in Taiwan. A comprehensive list of phenotypes was collected for …
individuals aged 20–70 in Taiwan. A comprehensive list of phenotypes was collected for …
[PDF][PDF] The HUNT Study: a population-based cohort for genetic research
BM Brumpton, S Graham, I Surakka, AH Skogholt… - Cell Genomics, 2022 - cell.com
Summary The Trøndelag Health Study (HUNT) is a population-based cohort of∼ 229,000
individuals recruited in four waves beginning in 1984 in Trøndelag County, Norway …
individuals recruited in four waves beginning in 1984 in Trøndelag County, Norway …
[PDF][PDF] Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversity
Asthma is a complex disease that varies widely in prevalence across populations. The
extent to which genetic variation contributes to these disparities is unclear, as the genetics …
extent to which genetic variation contributes to these disparities is unclear, as the genetics …
Prediction and stratification of longitudinal risk for chronic obstructive pulmonary disease across smoking behaviors
Smoking is the leading risk factor for chronic obstructive pulmonary disease (COPD)
worldwide, yet many people who never smoke develop COPD. We perform a longitudinal …
worldwide, yet many people who never smoke develop COPD. We perform a longitudinal …
Genetics of irritable bowel syndrome: shifting gear via biobank-scale studies
M Camilleri, A Zhernakova, I Bozzarelli… - Nature Reviews …, 2022 - nature.com
The pathophysiology of irritable bowel syndrome (IBS) is multifactorial and probably
involves genetic predisposition and the effect of environmental factors. Unlike other …
involves genetic predisposition and the effect of environmental factors. Unlike other …
[PDF][PDF] Leveraging global multi-ancestry meta-analysis in the study of idiopathic pulmonary fibrosis genetics
The research of rare and devastating orphan diseases, such as idiopathic pulmonary
fibrosis (IPF) has been limited by the rarity of the disease itself. The prognosis is poor—the …
fibrosis (IPF) has been limited by the rarity of the disease itself. The prognosis is poor—the …
Importance of diversity in precision medicine: Generalizability of genetic associations across ancestry groups toward better identification of disease susceptibility …
LA Cruz, JN Cooke Bailey… - Annual review of …, 2023 - annualreviews.org
Genome-wide association studies (GWAS) revolutionized our understanding of common
genetic variation and its impact on common human disease and traits. Developed and …
genetic variation and its impact on common human disease and traits. Developed and …
The All of Us Data and Research Center: Creating a Secure, Scalable, and Sustainable Ecosystem for Biomedical Research
KR Mayo, MA Basford, RJ Carroll… - Annual review of …, 2023 - annualreviews.org
The All of Us Research Program's Data and Research Center (DRC) was established to
help acquire, curate, and provide access to one of the world's largest and most diverse …
help acquire, curate, and provide access to one of the world's largest and most diverse …