Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …

One of the most important causes of neurological morbidity and mortality in the world is
ischemic stroke. It can be a result of multiple events such as embolism with a cardiac origin …

Abstract The 2017 ACC Expert Consensus Decision Pathway for Optimization of Heart
Failure Treatment was created to provide a practical, streamlined resource for clinicians …

Background Ischemic heart disease (IHD) is a leading cause of death worldwide. Also
referred to as coronary artery disease (CAD) and atherosclerotic cardiovascular disease …

Feature attributions based on the Shapley value are popular for explaining machine
learning models. However, their estimation is complex from both theoretical and …

Cell death is an essential feature of development in multicellular organisms, a critical driver
of degenerative diseases, and can be harnessed for treating some cancers. Understanding …

Tree-based machine learning models such as random forests, decision trees and gradient
boosted trees are popular nonlinear predictive models, yet comparatively little attention has …

Rationale: Maintaining iron homeostasis is essential for proper cardiac function. Both iron
deficiency and iron overload are associated with cardiomyopathy and heart failure via …

Stroke is the second leading cause of death and a major contributor to disability worldwide.
The prevalence of stroke is highest in developing countries, with ischemic stroke being the …

Atherosclerosis (AS) is the fundamental pathological state of many serious vascular
diseases, characterized by disorders of lipid metabolism. Ferroptosis is a type of regulated …