[HTML][HTML] Natural ingredients to improve immunity

A Gasmi, M Shanaida, O Oleshchuk, Y Semenova… - Pharmaceuticals, 2023 - mdpi.com
The immune system protects the body from infectious agents such as bacteria, viruses, or
fungi. Once encountered with pathogens or antigens, the innate and adaptive arms of the …

The role of SARS-CoV-2 nucleocapsid protein in antiviral immunity and vaccine development

H Yu, F Guan, H Miller, J Lei, C Liu - Emerging microbes & …, 2023 - Taylor & Francis
ABSTRACT The coronavirus disease 2019 (COVID-19) has caused enormous health risks
and global economic disruption. This disease is caused by the severe acute respiratory …

[HTML][HTML] Folic Acid and leucovorin have potential to prevent SARS-CoV-2-virus internalization by interacting with S-glycoprotein/neuropilin-1 receptor complex

R Škrbić, M Travar, MP Stojiljković, DM Djuric… - Molecules, 2023 - mdpi.com
The interaction of the SARS-CoV-2 spike (S) glycoprotein receptor-binding domain with the
host-cell ACE2 receptor is a well-known step in virus infection. Neuropilin-1 (NRP-1) is …

[HTML][HTML] An Integrated In Silico and In Vitro Approach for the Identification of Natural Products Active against SARS-CoV-2

R Pennisi, D Gentile, A Rescifina, E Napoli, P Trischitta… - Biomolecules, 2023 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has provoked a global health crisis due to the absence of a …

[HTML][HTML] The Role of Folic Acid in SARS-CoV-2 Infection: An Intriguing Linkage under Investigation

ND Karakousis, KI Gourgoulianis… - Journal of Personalized …, 2023 - mdpi.com
Background: SARS-CoV-2 is a life-threatening RNA virus that may cause an acute
respiratory syndrome associated with extremely high morbidity and mortality rates. Folic acid …

[HTML][HTML] Innovative, rapid, high-throughput method for drug repurposing in a pandemic—A case study of SARS-CoV-2 and COVID-19

SO Bello, A Yunusa, AA Adamu, MU Imam… - Frontiers in …, 2023 - frontiersin.org
Several efforts to repurpose drugs for COVID-19 treatment have largely either failed to
identify a suitable agent or agents identified did not translate to clinical use. Reasons that …

[HTML][HTML] 1, 7-Bis (4-hydroxyphenyl)-1, 4, 6-heptatrien-3-one inhibits SARS-CoV-2 by targeting the nucleocapsid protein

Y Liu, K Sa, W Xu, Y Chen, J Liang, P Zou… - Acta Materia …, 2023 - scienceopen.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally since
2020. The nucleocapsid (N) protein plays a crucial role in the life cycle of SARS-CoV-2 …

Molecular characterization of SARS-CoV-2 nucleocapsid protein

Y Huang, J Chen, S Chen, C Huang, B Li… - Frontiers in Cellular …, 2024 - frontiersin.org
Corona Virus Disease 2019 (COVID-19) is a highly prevalent and potent infectious disease
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Until now, the …

Applications of machine learning in computer-aided drug discovery

SMBA Turzo, ER Hantz, S Lindert - QRB discovery, 2022 - cambridge.org
Machine learning (ML) has revolutionised the field of structure-based drug design (SBDD) in
recent years. During the training stage, ML techniques typically analyse large amounts of …

[HTML][HTML] Clinical features and effectiveness of Chinese medicine in patients with COVID-19 from overseas: A retrospective study in xiamen, China

YX Huang, NF Li, CY Li, FP Zheng, XY Yao… - Frontiers in Public …, 2022 - frontiersin.org
COVID-19, referred to as new coronary pneumonia, is an acute infectious disease caused
by a new type of coronavirus SARS-CoV-2. To evaluate the effect of integrated Chinese …