X Hou, T Zaks, R Langer, Y Dong - Nature Reviews Materials, 2021 - nature.com
Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …
A drawback of the current mRNA-lipid nanoparticle (LNP) COVID-19 vaccines is that they have to be stored at (ultra) low temperatures. Understanding the root cause of the instability …
S Chen, X Huang, Y Xue, E Álvarez-Benedicto… - Nature Reviews …, 2023 - nature.com
Abstract mRNA vaccines have emerged as a revolutionary tool to generate rapid and precise immune responses against infectious diseases and cancers. Compared with …
GT Szabó, AJ Mahiny, I Vlatkovic - Molecular Therapy, 2022 - cell.com
Since the first successful application of messenger ribonucleic acid (mRNA) as a vaccine agent in a preclinical study nearly 30 years ago, numerous advances have been made in …
D Tian, Y Sun, J Zhou, Q Ye - Frontiers in immunology, 2021 - frontiersin.org
During the COVID-19 pandemic, SARS-CoV-2 variants have emerged and spread worldwide. The Delta (B. 1.617. 2) variant was first reported in India in October 2020 and …
Immune memory is tailored by cues that lymphocytes perceive during priming. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic created a situation in …
I McDonald, SM Murray, CJ Reynolds, DM Altmann… - npj Vaccines, 2021 - nature.com
As SARS-CoV-2 vaccines are deployed worldwide, a comparative evaluation is important to underpin decision-making. We here report a systematic literature review and meta-analysis …
Summary The SARS-CoV-2 spike (S) glycoprotein contains an immunodominant receptor- binding domain (RBD) targeted by most neutralizing antibodies (Abs) in COVID-19 patient …
X Ma, F Zou, F Yu, R Li, Y Yuan, Y Zhang, X Zhang… - Immunity, 2020 - cell.com
Various vaccine strategies have been proposed in response to the global COVID-19 pandemic, each with unique strategies for eliciting immune responses. Here, we developed …