Cell death and inflammation during obesity:“Know my methods, WAT (son)”

X Hildebrandt, M Ibrahim, N Peltzer - Cell Death & Differentiation, 2023 - nature.com
Obesity is a state of low-grade chronic inflammation that causes multiple metabolic
diseases. During obesity, signalling via cytokines of the TNF family mediate cell death and …

Potential therapeutic use of the rosemary diterpene carnosic acid for Alzheimer's disease, Parkinson's disease, and long-COVID through NRF2 activation to counteract …

T Satoh, D Trudler, CK Oh, SA Lipton - Antioxidants, 2022 - mdpi.com
Rosemary (Rosmarinus officinalis [family Lamiaceae]), an herb of economic and gustatory
repute, is employed in traditional medicines in many countries. Rosemary contains carnosic …

Links between COVID-19 and Parkinson's disease/Alzheimer's disease: reciprocal impacts, medical care strategies and underlying mechanisms

P Huang, LY Zhang, YY Tan, SD Chen - Translational Neurodegeneration, 2023 - Springer
The impact of coronavirus disease 2019 (COVID-19) pandemic on patients with
neurodegenerative diseases and the specific neurological manifestations of COVID-19 have …

Inflammatory caspases drive pyroptosis in acute lung injury

B Liu, R He, L Zhang, B Hao, W Jiang… - Frontiers in …, 2021 - frontiersin.org
Acute lung injury (ALI), a critical respiratory disorder that causes diffuse alveolar injury leads
to high mortality rates with no effective treatment. ALI is characterized by varying degrees of …

Adipose tissue inflammation and pulmonary dysfunction in obesity

G Palma, GP Sorice, VA Genchi, F Giordano… - International Journal of …, 2022 - mdpi.com
Obesity is a chronic disease caused by an excess of adipose tissue that may impair health
by altering the functionality of various organs, including the lungs. Excessive deposition of …

[HTML][HTML] Risks and burdens of incident dyslipidaemia in long COVID: a cohort study

E Xu, Y Xie, Z Al-Aly - The Lancet Diabetes & Endocrinology, 2023 - thelancet.com
Background Non-clinical evidence and a few human studies with short follow-ups suggest
increased risk of dyslipidaemia in the post-acute phase of COVID-19 (ie,> 30 days after …

Inflammation as a precursor of atherothrombosis, diabetes and early vascular aging

E Barbu, MR Popescu, AC Popescu… - International Journal of …, 2022 - mdpi.com
Vascular disease was for a long time considered a disease of the old age, but it is becoming
increasingly clear that a cumulus of factors can cause early vascular aging (EVA) …

[HTML][HTML] Metformin to decrease COVID-19 severity and mortality: Molecular mechanisms and therapeutic potential

O Kamyshnyi, V Matskevych, T Lenchuk… - Biomedicine & …, 2021 - Elsevier
The COVID-19 pandemic caused by the coronavirus SARS-CoV-2 has become a serious
challenge for medicine and science. Analysis of the molecular mechanisms associated with …

In COVID-19, NLRP3 inflammasome genetic variants are associated with critical disease and these effects are partly mediated by the sickness symptom complex: a …

M Maes, WLD Tedesco Junior, MAB Lozovoy… - Molecular …, 2022 - nature.com
Abstract In coronavirus disease (COVID-19), the nucleotide-binding domain, leucine-rich
repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome is activated in …

[HTML][HTML] NLRP3 inflammasome activation in COVID-19: an interlink between risk factors and disease severity

S Amin, S Aktar, MM Rahman, MMH Chowdhury - Microbes and infection, 2022 - Elsevier
NLRP3 inflammasome is a critical immune component that plays a crucial role in mounting
innate immune responses. The deleterious effects of inflammasome activation have been …