[HTML][HTML] From ARDS to pulmonary fibrosis: the next phase of the COVID-19 pandemic?

JE Michalski, JS Kurche, DA Schwartz - Translational Research, 2022 - Elsevier
While the coronavirus disease 19 (COVID-19) pandemic has transformed the medical and
scientific communites since it was first reported in late 2019, we are only beginning to …

The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance

EL Burnham, WJ Janssen, DWH Riches… - European respiratory …, 2014 - Eur Respiratory Soc
Acute respiratory distress syndrome (ARDS) continues to be a major healthcare problem,
affecting> 190 000 people in the USA annually, with a mortality of 27–45%, depending on …

[HTML][HTML] Integrating molecular pathogenesis and clinical translation in sepsis-induced acute respiratory distress syndrome

JA Englert, C Bobba, RM Baron - JCI insight, 2019 - ncbi.nlm.nih.gov
Sepsis-induced acute respiratory distress syndrome (ARDS) has high morbidity and
mortality and arises after lung infection or infection at extrapulmonary sites. An aberrant host …

Biomarkers in acute lung injury: insights into the pathogenesis of acute lung injury

LJM Cross, MA Matthay - Critical care clinics, 2011 - criticalcare.theclinics.com
The ability of the lung to perform gas exchange is made possible in part by the effective
relationship between the alveolar epithelium and the endothelium of the pulmonary …

Matrix metalloproteinases in acute lung injury: mediators of injury and drivers of repair

A Davey, DF McAuley… - European Respiratory …, 2011 - Eur Respiratory Soc
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) comprise a
spectrum of acute inflammatory pulmonary oedema resulting in refractory hypoxaemia in the …

Influenza virus infects epithelial stem/progenitor cells of the distal lung: impact on Fgfr2b-driven epithelial repair

J Quantius, C Schmoldt, AI Vazquez-Armendariz… - PLoS …, 2016 - journals.plos.org
Influenza Virus (IV) pneumonia is associated with severe damage of the lung epithelium and
respiratory failure. Apart from efficient host defense, structural repair of the injured epithelium …

Exploring the heterogeneity of effects of corticosteroids on acute respiratory distress syndrome: a systematic review and meta-analysis

SY Ruan, HH Lin, CT Huang, PH Kuo, HD Wu, CJ Yu - Critical care, 2014 - Springer
Introduction The effectiveness of corticosteroid therapy on the mortality of acute respiratory
distress syndrome (ARDS) remains under debate. We aimed to explore the grounds for the …

RGD‐binding integrins and TGF‐β in SARS‐CoV‐2 infections–novel targets to treat COVID‐19 patients?

I Carvacho, M Piesche - Clinical & Translational Immunology, 2021 - Wiley Online Library
The new coronavirus SARS‐CoV‐2 is a global pandemic and a severe public health crisis.
SARS‐CoV‐2 is highly contagious and shows high mortality rates, especially in elderly and …

Pulmonary vascular dysfunction in ARDS

D Ryan, S Frohlich, P McLoughlin - Annals of intensive care, 2014 - Springer
Acute respiratory distress syndrome (ARDS) is characterised by diffuse alveolar damage
and is frequently complicated by pulmonary hypertension (PH). Multiple factors may …

Enhanced resolution of experimental ARDS through IL-4-mediated lung macrophage reprogramming

FR D'Alessio, JM Craig, BD Singer… - … of Physiology-Lung …, 2016 - journals.physiology.org
Despite intense investigation, acute respiratory distress syndrome (ARDS) remains an
enormous clinical problem for which no specific therapies currently exist. In this study, we …