A detailed overview of immune escape, antibody escape, partial vaccine escape of SARS-CoV-2 and their emerging variants with escape mutations

C Chakraborty, AR Sharma, M Bhattacharya… - Frontiers in …, 2022 - frontiersin.org
The infective SARS-CoV-2 is more prone to immune escape. Presently, the significant
variants of SARS-CoV-2 are emerging in due course of time with substantial mutations …

SARS-CoV-2 vaccines, vaccine development technologies, and significant efforts in vaccine development during the pandemic: the lessons learned might help to fight …

C Chakraborty, M Bhattacharya, K Dhama - Vaccines, 2023 - mdpi.com
We are currently approaching three years since the beginning of the coronavirus disease
2019 (COVID-19) pandemic. SARS-CoV-2 has caused extensive disruptions in everyday …

Artificial intelligence enabled ChatGPT and large language models in drug target discovery, drug discovery, and development

C Chakraborty, M Bhattacharya, SS Lee - Molecular Therapy-Nucleic Acids, 2023 - cell.com
Drug discovery has been revolutionized recently by different computational approaches like
artificial intelligence (AI), deep learning (DL), and quantum mechanical methods. Drug …

A comprehensive review of drug repurposing strategies against known drug targets of COVID-19

A Khataniar, U Pathak, S Rajkhowa, AN Jha - Covid, 2022 - mdpi.com
Drug repurposing is a more inexpensive and shorter approach than the traditional drug
discovery and development process. The concept of identifying a potent molecule from a …

Spectrofluorimetric quantitative analysis of favipiravir, remdesivir and hydroxychloroquine in spiked human plasma

S Ramzy, AH Abdelazim, AOE Osman… - Spectrochimica Acta Part …, 2022 - Elsevier
Favipiravir, remdesivir and hydroxychloroquine have been suggested in COVID-19
Treatment Guidelines Panel of many countries. Synchronous spectrofluorometric …

Streptomyces learnhanii sp. nov., unveiling a Mangrove-Derived Novel “Modern Actinobacteria” in Malaysia

JWF Law, V Letchumanan… - … In Microbes & …, 2023 - journals.hh-publisher.com
Streptomyces learnhanii sp. nov. MUM 203J T was isolated from Malaysia mangrove soil.
This Gram-positive bacterium produces pale greenish-yellow aerial and greyish-yellow …

Resistance to nirmatrelvir due to mutations in the Mpro in the subvariants of SARS-CoV-2 Omicron: Another concern?

S Chatterjee, M Bhattacharya, K Dhama, SS Lee… - … Therapy-Nucleic Acids, 2023 - cell.com
The world has faced 3 years of the COVID-19 pandemic with billions of infections, millions of
deaths, and a massive economic crisis. Since the pandemic began, scientists have started to …

Parents' attitudes, their acceptance of the COVID-19 vaccines for children and the contributing factors in Najran, Saudi Arabia: a cross-sectional survey

AI Aedh - Vaccines, 2022 - mdpi.com
Background: The COVID-19 pandemic is still ongoing, so it is critical to immunize the
majority of people, including children, to achieve herd immunity against the pandemic. As …

Quercetin as a possible complementary agent for early-stage COVID-19: Concluding results of a randomized clinical trial

F Di Pierro, A Khan, S Iqtadar, SU Mumtaz… - Frontiers in …, 2023 - frontiersin.org
Background: Quercetin, a natural polyphenol with demonstrated broad-spectrum antiviral,
anti-inflammatory, and antioxidant properties, has been proposed as an adjuvant for early …

Emerging mutations in the SARS-CoV-2 variants and their role in antibody escape to small molecule-based therapeutic resistance

C Chakraborty, M Bhattacharya, AR Sharma - Current Opinion in …, 2022 - Elsevier
Several clinical trials started during the COVID-19 pandemic to discover effective
therapeutics led to identify a few candidates from the major clinical trials. However, in the …