Transposable elements (TEs) comprise about half of the mammalian genome. TEs often
contain sequences capable of recruiting the host transcription machinery, which they use to …

Mammalian fertilization begins with the fusion of two specialized gametes, followed by major
epigenetic remodeling leading to the formation of a totipotent embryo. During the …

Zygotic genome activation (ZGA) is a critical postfertilization step that promotes totipotency
and allows different cell fates to emerge in the developing embryo. MERVL (murine …

Totipotent cells have more robust developmental potency than any other cell types, giving
rise to both embryonic and extraembryonic tissues. Stable totipotent cell cultures and …

Background Histone lysine-specific demethylase 1 (LSD1) expression has been shown to
be significantly elevated in gastric cancer (GC) and may be associated with the proliferation …

Endogenous retroviruses (ERVs) are emerging as promising therapeutic targets in cancer.
As remnants of ancient retroviral infections, ERV-derived regulatory elements coordinate …

Totipotency emerges in early embryogenesis, but its molecular underpinnings remain poorly
characterized. In the present study, we employed DNA fiber analysis to investigate how …

The smooth and precise transition from totipotency to pluripotency is a key process in
embryonic development, generating pluripotent stem cells capable of forming all cell types …

Zygotic genome activation (ZGA) is an essential transcriptional event in embryonic
development that coincides with extensive epigenetic reprogramming. Complex …

Differentiated somatic cells can be reprogrammed to totipotent embryos through somatic cell
nuclear transfer (SCNT) with low efficiency. The histone deacetylase inhibitor trichostatin A …