Deconvoluting complex correlates of COVID-19 severity with a multi-omic pandemic tracking strategy
VN Parikh, AG Ioannidis, D Jimenez-Morales… - Nature …, 2022 - nature.com
The SARS-CoV-2 pandemic has differentially impacted populations across race and
ethnicity. A multi-omic approach represents a powerful tool to examine risk across multi …
ethnicity. A multi-omic approach represents a powerful tool to examine risk across multi …
Genetic risk factors for COVID-19 and influenza are largely distinct
Abstract Coronavirus disease 2019 (COVID-19) and influenza are respiratory illnesses
caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and …
caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and …
Human genetic basis of severe or critical illness in COVID-19
XS Ji, B Chen, B Ze, WH Zhou - Frontiers in cellular and infection …, 2022 - frontiersin.org
Coronavirus Disease 2019 (COVID-19) caused by the novel severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has led to considerable morbidity and mortality …
syndrome coronavirus 2 (SARS-CoV-2) has led to considerable morbidity and mortality …
Host genetics of pediatric SARS-CoV-2 COVID-19 and multisystem inflammatory syndrome in children
GS Schulert, SA Blum, RQ Cron - Current opinion in pediatrics, 2021 - journals.lww.com
Several genetic associations have been identified in individuals with severe COVID-19 and
MIS-C via various genetic approaches. Broadly speaking, COVID-19 genetic associations …
MIS-C via various genetic approaches. Broadly speaking, COVID-19 genetic associations …
Exome sequencing of 628,388 individuals identifies common and rare variant associations with clonal hematopoiesis phenotypes
Clonal hematopoiesis (CH) refers to the expansion of certain blood cell lineages and has
been associated with aging and adverse health outcomes. Here, we use exome sequence …
been associated with aging and adverse health outcomes. Here, we use exome sequence …
The role of admixture in the rare variant contribution to inflammatory bowel disease
Background Identification of rare variants involved in complex, polygenic diseases like
Crohn's disease (CD) has accelerated with the introduction of whole exome/genome …
Crohn's disease (CD) has accelerated with the introduction of whole exome/genome …
Genetics of COVID‐19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review
Abstract COVID‐19 and ME/CFS present with some similar symptoms, especially physical
and mental fatigue. In order to understand the basis of these similarities and the possibility of …
and mental fatigue. In order to understand the basis of these similarities and the possibility of …
Optical genome mapping identifies rare structural variations as predisposition factors associated with severe COVID-19
Impressive global efforts have identified both rare and common gene variants associated
with severe COVID-19 using sequencing technologies. However, these studies lack the …
with severe COVID-19 using sequencing technologies. However, these studies lack the …
Systematic review of host genetic association with Covid‐19 prognosis and susceptibility: What have we learned in 2020?
JL Ferreira de Araujo, D Menezes… - Reviews in medical …, 2022 - Wiley Online Library
Biomarker identification may provide strategic opportunities to understand disease
pathophysiology, predict outcomes, improve human health, and reduce healthcare costs …
pathophysiology, predict outcomes, improve human health, and reduce healthcare costs …
Presence of rare potential pathogenic variants in subjects under 65 years old with very severe or fatal COVID-19
R López-Rodríguez, M Del Pozo-Valero, M Corton… - Scientific reports, 2022 - nature.com
Rare variants affecting host defense against pathogens could be involved in COVID-19
severity and may help explain fatal outcomes in young and middle-aged patients. Our aim …
severity and may help explain fatal outcomes in young and middle-aged patients. Our aim …