Abstract Treatment resistant schizophrenia (TRS) refers to the significant proportion of
schizophrenia patients who continue to have symptoms and poor outcomes despite …

Recent large-scale genomic studies have revealed two broad classes of risk alleles for
schizophrenia: a polygenic component of risk mediated through multiple common risk …

Abstract Background Polygenic risk scores (PRSs) have successfully summarized genome-
wide effects of genetic variants in schizophrenia with significant predictive power. In a …

Over 100 loci are now associated with schizophrenia risk as identified by single nucleotide
polymorphisms (SNPs) in genome-wide association studies. These findings mean that …

The origins of schizophrenia have eluded clinicians and researchers since Kraepelin and
Bleuler began documenting their findings. However, large clinical research efforts in recent …

Although both schizophrenia and gray matter volume (GMV) show high heritability, however,
genes accounting for GMV alterations in schizophrenia remain largely unknown. Based on …

Importance Advancing paternal age has been linked to autism. Objective To further expand
knowledge about the association between paternal age and autism by studying the effect of …

Research into the neurobiological processes that may lead to the onset of schizophrenia
places growing emphasis on the glutamatergic system and brain development. Preclinical …

While much progress has been made in identifying the brain regions and neurochemical
systems involved in the cognitive processes disrupted in mental illnesses, to date, the level …

The subplate zone is a highly dynamic transient sector of the developing cerebral cortex that
contains some of the earliest generated neurons and the first functional synapses of the …