Diabetic cardiomyopathy (DCM) is a chronic complication of diabetes mellitus, characterized
by abnormalities of myocardial structure and function. Researches on the models of type 1 …

Fibrosis is a chronic and progressive disorder characterized by excessive deposition of
extracellular matrix, which leads to scarring and loss of function of the affected organ or …

Heart failure is one of the leading causes of death and disability worldwide. Left ventricle
remodeling, fibrosis, and ischemia/reperfusion injury all contribute to the deterioration of …

Abstract UNC-51-like kinase 1 (ULK1), as a serine/threonine kinase, is an autophagic
initiator in mammals and a homologous protein of autophagy related protein (Atg) 1 in yeast …

Background Induced pluripotent stem cells and their differentiated cardiomyocytes (iCM s)
have tremendous potential as patient‐specific therapy for ischemic cardiomyopathy …

Background Therapies are urgently required to ameliorate pathological cardiac hypertrophy
and enhance cardiac function in heart failure. Our preliminary experiments have …

Diabetes mellitus (DM) is a chronic metabolic disease caused by a complex interaction of
genetic and environmental factors and is characterized by persistent hyperglycemia. Long …

Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic proteins
and organelles, which realizes the metabolic needs of cells and the renewal of organelles …

Cardiovascular diseases are one of the leading causes of death worldwide and cardiac
fibrosis is a common pathological process for cardiac remodeling in cardiovascular …

Atrial fibrillation (AF) is the common arrhythmias. Myocardial fibrosis (MF) is closely related
to atrial remodeling and leads to AF. MF is the main cause of cardiovascular diseases and a …