Gut inflammation is strongly associated with spondyloarthritis (SpA), as exemplified by the
high prevalence of inflammatory bowel disease (IBD) and the even higher occurrence of …

The orphan G-protein-coupled receptor 35 (GPR35), although poorly characterised, is
attracting considerable interest as a therapeutic target. Marked differences in pharmacology …

Rapid neutrophil recruitment to sites of inflammation is crucial for innate immune responses.
Here, we reveal that the G-protein-coupled receptor GPR35 is upregulated in activated …

Neutrophil recruitment from circulation to sites of inflammation is guided by multiple
chemoattractant cues emanating from tissue cells, immune cells, and platelets. Here, we …

Single-nucleotide polymorphisms in the gene encoding G protein-coupled receptor 35
(GPR35) are associated with increased risk of inflammatory bowel disease. However, the …

GPR35 is a class A, rhodopsin-like G protein-coupled receptor (GPCR) first identified more
than 20 years ago. In the intervening period, identification of strong expression in the lower …

The intricate interplay between gut microbes and the onset of experimental autoimmune
encephalomyelitis (EAE) remains poorly understood. Here, we uncover remarkable …

Diet and gut microbial metabolites mediate host immune responses and are central to the
maintenance of intestinal health. The metabolite-sensing G-protein coupled receptors …

Increasing evidence has indicated that diet and metabolites, including bacteria-and host-
derived metabolites, orchestrate host pathophysiology by regulating metabolism, immune …

Within the intestine, the human G protein–coupled receptor (GPCR) GPR35 is involved in
oncogenic signaling, bacterial infections, and inflammatory bowel disease. GPR35 is known …