Tissue localization is a critical determinant of T cell immunity. CD8+ T cells are contact-
dependent killers, which requires them to physically be within the tissue of interest to kill …

Over the last decade remarkable progress has been made in enhancing the efficacy of CAR
T therapies. However, the clinical benefits are still limited, especially in solid tumors. Even in …

Adoptive transfer of genetically engineered chimeric antigen receptor (CAR) T cells is
becoming a promising treatment option for hematological malignancies. However, T cell …

Vaccines have been a hugely successful public health intervention, virtually eliminating
many once common diseases of childhood. However, they have had less success in …

Our skin contributes critically to health via its role as a barrier tissue, carefully regulating
passage of key substrates while also providing defense against exogenous threats …

Leukocyte trafficking between blood and tissues is an essential function of the immune
system that facilitates humoral and cellular immune responses. Within tissues, leukocytes …

Abnormal immune cell functions are commonly related to various diseases, including
cancer, autoimmune diseases, and infectious diseases. Messenger RNA (mRNA)-based …

The tissues are the site of many important immunological reactions, yet how the immune
system is controlled at these sites remains opaque. Recent studies have identified Foxp3+ …

Cell migration is crucial for many biological processes, including normal development,
immune response, and tissue homeostasis and many pathological processes such as …

Increased immune cell infiltration into tumors is associated with improved patient survival
and predicts response to immune therapies. Thus, identification of factors that determine the …