Saponins: research progress and their potential role in the Post-COVID-19 pandemic Era

D Mieres-Castro, F Mora-Poblete - Pharmaceutics, 2023 - mdpi.com
In the post-COVID-19 pandemic era, the new global situation and the limited therapeutic
management of the disease make it necessary to take urgent measures in more effective …

Anti-COVID-19 Potential of Ellagic Acid and Polyphenols of Punica granatum L.

R Alexova, S Alexandrova, S Dragomanova, R Kalfin… - Molecules, 2023 - mdpi.com
Pomegranate (Punica granatum L.) is a rich source of polyphenols, including ellagitannins
and ellagic acid. The plant is used in traditional medicine, and its purified components can …

The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2

HF Chen, WJ Wang, CY Chen, WC Chang, PR Hsueh… - eLife, 2023 - elifesciences.org
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic continues to infect people
worldwide. While the vaccinated population has been increasing, the rising breakthrough …

Molecular docking and molecular dynamics simulation of fisetin, galangin, hesperetin, hesperidin, myricetin, and naringenin against polymerase of dengue virus

JF Fatriansyah, RK Rizqillah… - Journal of tropical …, 2022 - Wiley Online Library
Dengue fever is a disease spread by the DENV virus through mosquitoes. This disease is
dangerous because there is no specific drug, vaccine, or antiviral against the DENV virus …

Target-based drug discovery, ADMET profiling and bioactivity studies of antibiotics as potential inhibitors of SARS-CoV-2 main protease (Mpro)

M Abdul-Hammed, IO Adedotun, VA Falade… - Virusdisease, 2021 - Springer
A recent outbreak of a new strain of Coronavirus (SARS-CoV-2) has become a global health
burden, which has resulted in deaths. No proven drug has been found to effectively cure this …

In Vitro effects of petroleum ether, dichloromethane, methanolic and aqueous leaf extracts of Eucalyptus grandis on selected multidrug-resistant bacteria

B Kwansa-Bentum, BA Okine, AD Dayie… - PLoS …, 2023 - journals.plos.org
Background The emergence and spread of antimicrobial resistance is of grave concern,
requiring the search for newer and more effective antimicrobials to combat infections caused …

The main protease of SARS-CoV-2 as a target for phytochemicals against coronavirus

SS Issa, SV Sokornova, RR Zhidkin, TV Matveeva - Plants, 2022 - mdpi.com
In late December 2019, the first cases of COVID-19 emerged as an outbreak in Wuhan,
China that later spread vastly around the world, evolving into a pandemic and one of the …

Novel Drug Design for Treatment of COVID‐19: A Systematic Review of Preclinical Studies

S Mousavi, S Zare, M Mirzaei… - Canadian Journal of …, 2022 - Wiley Online Library
Background. Since the beginning of the novel coronavirus (SARS‐CoV‐2) disease
outbreak, there has been an increasing interest in discovering potential therapeutic agents …

Network analytics for drug repurposing in COVID-19

N Siminea, V Popescu… - Briefings in …, 2022 - academic.oup.com
To better understand the potential of drug repurposing in COVID-19, we analyzed control
strategies over essential host factors for SARS-CoV-2 infection. We constructed …

In vitro antiplasmodial, molecular docking and pharmacokinetics studies of specialized metabolites from Tetrapleura tetraptera (Fabaceae)

KG Sikam, GM Happi, SA Ahmed, BNK Wakeu… - South African Journal of …, 2022 - Elsevier
Tetrapleura tetraptera is a well-known plant widely used in Cameroon as spices in cooking
and in preparations prescribed in folk medicine for the treatment of malaria. The main …