Abnormal increases in cell size are associated with senescence and cell cycle exit. The
mechanisms by which overgrowth primes cells to withdraw from the cell cycle remain …

Years of important research has revealed that cells heavily invest in regulating their size.
Nevertheless, it has remained unclear why accurate size control is so important. Our recent …

Cellular senescence refers to an irreversible state of cell-cycle arrest and plays important
roles in aging and cancer biology. Because senescence is associated with increased cell …

Background Aging is characterized by an ongoing struggle between the buildup of damage
caused by a combination of external and internal factors. Aging has different effects on …

Abstract Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors are approved for breast cancer
treatment and show activity against other malignancies, including KRAS-mutant non–small …

Background A form of cancer that affects the rectum or colon (large intestine) is called
colorectal cancer (CRC). The main risk factors for CRC include dietary, lifestyle, and …

CDK4/6 inhibitors are effective at treating advanced HR+/HER2-breast cancer, however
biomarkers that can predict response are urgently needed. We demonstrate here that …

Too big not to fail: Different paths lead to senescence of enlarged cells: Molecular Cell Skip to
Main Content Advertisement Molecular Cell This journal offers authors two options (open access …

Cell cycle dysregulation is a hallmark of cancer that promotes eccessive cell division. Cyclin-
dependent kinase 4 (CDK4) and cyclin-dependent kinase 6 (CDK6) are key molecules in …

Cellular senescence refers to a permanent and stable state of cell cycle exit. This process
plays an important role in many cellular functions, including tumor suppression. It was first …