The ongoing COVID-19 pandemic has resulted in millions of deaths globally, highlighting
the need to develop potent prophylactic and therapeutic strategies against SARS-CoV-2 …

The current monkeypox outbreaks during the COVID-19 pandemic have reignited interest in
orthopoxvirus antivirals. Monkeypox belongs to the Orthopoxvirus genus of the Poxviridae …

The SARS-CoV-2 main protease (Mpro) is the drug target of Pfizer's oral drug nirmatrelvir.
The emergence of SARS-CoV-2 variants with mutations in Mpro raised the alarm of potential …

Abstract SARS-CoV-2 main protease (M pro) is a validated antiviral drug target of
nirmatrelvir, the active ingredient in Pfizer's oral drug Paxlovid. Drug-drug interactions limit …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a serious
global public health threat. The evolving strains of SARS-CoV-2 have reduced the …

The global pandemic of COVID‐19 is considered one of the most catastrophic events on
earth. During the pandemic, food ingredients may play crucial roles in preventing infectious …

By combining docking and molecular dynamics simulations, we explored a library of 65
mostly axially chiral naphthylisoquinoline alkaloids and their analogues, with most different …

In this paper, a series of peptidomimetic SARS-CoV-2 3CL protease inhibitors with new P2
and P4 positions were synthesized and evaluated. Among these compounds, 1a and 2b …

The COVID-19 pandemic is caused by SARS-CoV-2, an RNA virus with high transmissibility
and mutation rate. Given the paucity of orally bioavailable antiviral drugs to combat SARS …

The ongoing transmission of SARS-CoV-2 necessitates the development of additional
potent antiviral agents capable of combating the current highly infectious variants and future …