Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders

A Khan, M Ikram, JR Hahm, MO Kim - Antioxidants, 2020 - mdpi.com
Neurodegenerative disorders have emerged as a serious health issue in the current era.
The most common neurodegenerative disorders are Alzheimer's disease (AD), Parkinson's …

Neuroprotective effects and therapeutic potential of the citrus flavonoid hesperetin in neurodegenerative diseases

JA Evans, P Mendonca, KFA Soliman - Nutrients, 2022 - mdpi.com
Neurodegenerative disorders affect more than fifty million Americans each year and
represent serious health threats as the population ages. Neuroinflammation and oxidative …

Hesperetin, a citrus flavonoid, attenuates LPS-induced neuroinflammation, apoptosis and memory impairments by modulating TLR4/NF-κB signaling

T Muhammad, M Ikram, R Ullah, SU Rehman, MO Kim - Nutrients, 2019 - mdpi.com
Glial activation and neuroinflammation play significant roles in apoptosis as well as in the
development of cognitive and memory deficits. Neuroinflammation is also a critical feature in …

Bioavailability of hesperidin and its aglycone hesperetin—compounds found in citrus fruits as a parameter conditioning the pro-health potential (neuroprotective and …

K Wdowiak, J Walkowiak, R Pietrzak, A Bazan-Woźniak… - Nutrients, 2022 - mdpi.com
Hesperidin and hesperetin are polyphenols that can be found predominantly in citrus fruits.
They possess a variety of pharmacological properties such as neuroprotective and …

[HTML][HTML] Habitual intake of anthocyanins and flavanones and risk of cardiovascular disease in men

A Cassidy, M Bertoia, S Chiuve, A Flint… - The American journal of …, 2016 - Elsevier
Background: Although increased fruit intake reduces cardiovascular disease (CVD) risk,
which fruits are most beneficial and what key constituents are responsible are unclear …

Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 …

AM Mahmoud, MB Ashour, A Abdel-Moneim… - Journal of Diabetes and …, 2012 - Elsevier
Abnormal regulation of glucose and impaired carbohydrate utilization that result from a
defective or deficient insulin are the key pathogenic events in type 2 diabetes mellitus …

Hesperetin confers neuroprotection by regulating Nrf2/TLR4/NF-κB signaling in an Aβ mouse model

M Ikram, T Muhammad, SU Rehman, A Khan… - Molecular …, 2019 - Springer
Hesperetin is a bioactive flavonoid in the body, produced from hesperidin. No
comprehensive studies have shown its protective effects in neurodegenerative disorders …

Chemotherapeutic potential of hesperetin for cancer treatment, with mechanistic insights: A comprehensive review

M Sohel, H Sultana, T Sultana, M Al Amin, S Aktar… - Heliyon, 2022 - cell.com
Background Cancer has become a significant concern in the medical sector with increasing
disease complexity. Although some available conventional treatments are still a blessing for …

[HTML][HTML] Anti-inflammatory phytochemicals for the treatment of diabetes and its complications: Lessons learned and future promise

M Kong, K Xie, M Lv, J Li, J Yao, K Yan, X Wu… - Biomedicine & …, 2021 - Elsevier
Diabetes mellitus (type 1 and type 2) and its various complications continue to place a huge
burden on global medical resources, despite the availability of numerous drugs that …

Neuroprotective effects of citrus flavonoids

SL Hwang, PH Shih, GC Yen - Journal of Agricultural and Food …, 2012 - ACS Publications
Recent attention has been given to the influence of dietary factors on health and mental well-
being. Oxidative stress is associated with many diseases including neurodegenerative …