The role of cytokines and chemokines in severe acute respiratory syndrome coronavirus 2 infections

RJ Hsu, WC Yu, GR Peng, CH Ye, SY Hu… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in countless
infections and caused millions of deaths since its emergence in 2019. Coronavirus disease …

The role of interleukin-8 in lung inflammation and injury: implications for the management of COVID-19 and hyperinflammatory acute respiratory distress syndrome

MC Cesta, M Zippoli, C Marsiglia, EM Gavioli… - Frontiers in …, 2022 - frontiersin.org
Severe Acute Respiratory Syndrome Coronavirus—2 (SARS CoV-2) has resulted in the
global spread of Coronavirus Disease 2019 (COVID-19) and an increase in complications …

Neutrophils in COVID-19: not innocent bystanders

E McKenna, R Wubben, JM Isaza-Correa… - Frontiers in …, 2022 - frontiersin.org
Unusually for a viral infection, the immunological phenotype of severe COVID-19 is
characterised by a depleted lymphocyte and elevated neutrophil count, with the neutrophil …

Dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status in the USA: a prospective cohort study

X Zhu, KA Gebo, AG Abraham, F Habtehyimer… - The Lancet …, 2023 - thelancet.com
Background Cytokines and chemokines play a critical role in the response to infection and
vaccination. We aimed to assess the longitudinal association of COVID-19 vaccination with …

Safety and long-term improvement of mesenchymal stromal cell infusion in critically COVID-19 patients: a randomized clinical trial

CLK Rebelatto, AC Senegaglia, CL Franck… - Stem cell research & …, 2022 - Springer
Background COVID-19 is a multisystem disease that presents acute and persistent
symptoms, the postacute sequelae (PASC). Long-term symptoms may be due to …

Associations between Serum Interleukins (IL‐1β, IL‐2, IL‐4, IL‐6, IL‐8, and IL‐10) and Disease Severity of COVID‐19: A Systematic Review and Meta‐Analysis

Y Chang, M Bai, Q You - BioMed Research International, 2022 - Wiley Online Library
Background. To investigate the association between interleukins (IL‐1β, IL‐2, IL‐4, IL‐6, IL‐
8, and IL‐10) and the disease severity of coronavirus disease 2019 (COVID‐19). Materials …

Association between inflammatory cytokines and anti-SARS-CoV-2 antibodies in hospitalized patients with COVID-19

X Jing, M Xu, D Song, T Yue, Y Wang, P Zhang… - Immunity & …, 2022 - Springer
Background COVID-19 patients may experience “cytokine storm” when human immune
system produces excessive cytokines/chemokines. However, it remains unclear whether …

TLRs: innate immune sentries against SARS-CoV-2 infection

S Mantovani, B Oliviero, S Varchetta, A Renieri… - International Journal of …, 2023 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has been responsible for a devastating pandemic since March …

Age-dependent immune responses in COVID-19-mediated liver injury: focus on cytokines

N Aghamohamadi, F Shahba… - Frontiers in …, 2023 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is potentially pathogenic
and causes severe symptoms; in addition to respiratory syndromes, patients might …

Colchicine is safe though ineffective in the treatment of severe COVID-19: a randomized clinical trial (COLCHIVID)

A Absalon-Aguilar, M Rull-Gabayet… - Journal of General …, 2022 - Springer
Background Colchicine is an available, safe, and effective anti-inflammatory drug and has
been suggested as a COVID-19 treatment, but its usefulness in hospitalized severe COVID …