Understanding how human genetics influence infectious disease susceptibility offers the
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …

Studies in diverse biological systems have indicated that host–parasite co-evolution is
responsible for the extraordinary genetic diversity seen in some genomic regions, such as …

The current rate of species extinction is rapidly approaching unprecedented highs, and life
on Earth presently faces a sixth mass extinction event driven by anthropogenic activity …

Personalized genome sequencing has revealed millions of genetic differences between
individuals, but our understanding of their clinical relevance remains largely incomplete. To …

The ancient biological'arms race'between microbial pathogens and humans has shaped
genetic variation in modern populations, and this has important implications for the growing …

In many species, genomic data have revealed pervasive adaptive evolution indicated by the
fixation of beneficial alleles. However, when selection pressures are highly variable along a …

Across diverse taxa, selfing species have evolved independently from outcrossing species
thousands of times. The transition from outcrossing to selfing decreases the effective …

Detection of recent natural selection is a challenging problem in population genetics. Here
we introduce the singleton density score (SDS), a method to infer very recent changes in …

Because germline mutations are the source of all evolutionary adaptations and heritable
diseases, characterizing their properties and the rate at which they arise across individuals …

The complex correlation structure of a collection of orthologous DNA sequences is uniquely
captured by the “ancestral recombination graph”(ARG), a complete record of coalescence …