[HTML][HTML] The role of beta-2-glycoprotein I in health and disease associating structure with function: More than just APS

T McDonnell, C Wincup, I Buchholz, C Pericleous… - Blood reviews, 2020 - Elsevier
Abstract Beta-2-Glycoprotein I (β2GPI) plays a number of essential roles throughout the
body. β2GPI, C-reactive protein and thrombomodulin are the only three proteins that …

From co-infections to autoimmune disease via hyperactivated innate immunity: COVID-19 autoimmune coagulopathies, autoimmune myocarditis and multisystem …

R Root-Bernstein - International Journal of Molecular Sciences, 2023 - mdpi.com
Neutrophilia and the production of neutrophil extracellular traps (NETs) are two of many
measures of increased inflammation in severe COVID-19 that also accompany its …

Platelet-derived microparticles stimulated by anti-β2GPI/β2GPI complexes induce pyroptosis of endothelial cells in antiphospholipid syndrome

L Di, C Zha, Y Liu - Platelets, 2023 - Taylor & Francis
Platelet microparticles (PMPs) are vesicles that are released by platelets into the
extracellular space and play a role in antiphospholipid antibody syndromes. PMPs have …

Circulating immune-complexes of IgG/IgM bound to B2-glycoprotein-I associated with complement consumption and thrombocytopenia in antiphospholipid syndrome

L Naranjo, L Stojanovich, A Djokovic… - Frontiers in …, 2022 - frontiersin.org
Background Antiphospholipid syndrome (APS) is a multisystemic autoimmune disorder
characterized by thrombotic events and/or gestational morbidity in patients with …

Antigens and antibodies of the antiphospholipid syndrome as new allies in the pathogenesis of COVID-19 coagulopathy

M Serrano, G Espinosa, A Serrano… - International Journal of …, 2022 - mdpi.com
High prevalence of both criteria and extra-criteria antiphospholipid antibodies (aPL) has
been reported in COVID-19 patients. However, the differences in aPL prevalence decreased …

Incidence of thromboembolic events in asymptomatic carriers of IgA anti ss2 glycoprotein-I antibodies

C Tortosa, O Cabrera-Marante, M Serrano… - PLoS …, 2017 - journals.plos.org
Background The antiphospholipid syndrome (APS) is defined by simultaneous presence of
vascular clinical events and antiphospholipid antibodies (aPL). The aPL considered as …

Case report: Resetting the humoral immune response by targeting plasma cells with daratumumab in anti-phospholipid syndrome

DE Pleguezuelo, R Díaz-Simón… - Frontiers in …, 2021 - frontiersin.org
Introduction Monoclonal antibodies (mAb) targeting plasma cells are malignant
gammopathy designed and approved therapies. In recent years, these antibodies have also …

β2-Glycoprotein I/IgA Immune Complexes: A Marker to Predict Thrombosis After Renal Transplantation in Patients With Antiphospholipid Antibodies

M Serrano, JA Martínez-Flores, D Pérez, F García… - Circulation, 2017 - Am Heart Assoc
Background: Antiphospholipid syndrome is characterized by recurrent thrombosis and
gestational morbidity in patients with antiphospholipid autoantibodies (aPLs). Predictive …

Antiphospholipid syndrome and renal allograft thrombosis

JM Morales, M Serrano, JA Martinez-Flores… - …, 2019 - journals.lww.com
Renal allograft thrombosis is the most frequent and devastating complication in the early
postrenal transplantation period. Several risk factors to develop graft thrombosis depending …

Presence of immune complexes of IgG/IgM bound to B2-glycoprotein I is associated with non-criteria clinical manifestations in patients with antiphospholipid syndrome

D Pérez, L Stojanovich, L Naranjo… - Frontiers in …, 2018 - frontiersin.org
Background: Antiphospholipid syndrome (APS) is an acquired autoimmune disorder defined
by the presence of both clinical (thromboembolic events or pregnancy morbidity) and …