Concise review: mesenchymal stem (stromal) cells: biology and preclinical evidence for therapeutic potential for organ dysfunction following trauma or sepsis

MA Matthay, S Pati, JW Lee - Stem Cells, 2017 - academic.oup.com
Several experimental studies have provided evidence that bone-marrow derived
mesenchymal stem (stromal) cells (MSC) may be effective in treating critically ill surgical …

Therapeutic applications of stem cells and extracellular vesicles in emergency care: futuristic perspectives

S Öztürk, AE Elçin, A Koca, YM Elçin - Stem Cell Reviews and Reports, 2021 - Springer
Regenerative medicine (RM) is an interdisciplinary field that aims to repair, replace or
regenerate damaged or missing tissue or organs to function as close as possible to its …

Procoagulant activity of human mesenchymal stem cells

BA Christy, MC Herzig, RK Montgomery… - Journal of Trauma …, 2017 - journals.lww.com
BACKGROUND Allogeneic mesenchymal stem cells (MSCs) show great potential for the
treatment of military and civilian trauma based on their reduced immunogenicity and ability …

Mesenchymal stem cell-derived extracellular vesicles attenuate pulmonary vascular permeability and lung injury induced by hemorrhagic shock and trauma

DR Potter, BY Miyazawa, SL Gibb, X Deng… - Journal of Trauma …, 2018 - journals.lww.com
BACKGROUND Mesenchymal stem cells (MSCs) have been shown to mitigate vascular
permeability in hemorrhagic shock (HS) and trauma-induced brain and lung injury …

Freeze-dried extracellular vesicles from adipose-derived stem cells prevent hypoxia-induced muscle cell injury

KBY El Baradie, M Nouh, F O'Brien III, Y Liu… - Frontiers in cell and …, 2020 - frontiersin.org
Cellular therapies have tremendous potential for the successful treatment of major extremity
wounds in the combat setting, however, the challenges associated with transplanting stem …

Application of bone marrow–derived mesenchymal stem cells for muscle healing after contusion injury in mice

CH Chiu, TH Chang, SS Chang… - … American journal of …, 2020 - journals.sagepub.com
Background: Skeletal muscle injuries are very common in sports medicine. Conventional
therapies have limited clinical efficacy. New treatment methods should be developed to …

Mesenchymal stromal cell and bone marrow concentrate therapies for musculoskeletal indications: a concise review of current literature

C Eder, K Schmidt-Bleek, S Geissler, FA Sass… - Molecular Biology …, 2020 - Springer
The interest on applying mesenchymal stromal cells (MSCs) in orthopedic disorders has
risen tremendously in the last years due to scientific successes in preclinical in vitro and …

The promise of mesenchymal stem cell therapy for acute respiratory distress syndrome

B Antebi, A Mohammadipoor… - Journal of Trauma …, 2018 - journals.lww.com
This review describes the current state of the science on mesenchymal stem cell (MSC)
treatment for acute lung injury (ALI). The general characteristics, regenerative potential, and …

Mesenchymal stem cell extracellular vesicles mitigate vascular permeability and injury in the small intestine and lung in a mouse model of hemorrhagic shock and …

M Barry, A Trivedi, P Pathipati… - Journal of Trauma …, 2022 - journals.lww.com
BACKGROUND Hemorrhagic shock and trauma (HS/T)-induced gut injury may play a critical
role in the development of multi-organ failure. Novel therapies that target gut injury and …

Platelet-derived microvesicles: a potential therapy for trauma-induced coagulopathy

E Lopez, AK Srivastava, S Pati, JB Holcomb, CE Wade - Shock, 2018 - journals.lww.com
Trauma patients are often affected by a hypocoagulable condition referred to as trauma-
induced coagulopathy (TIC) for which few therapeutic options exist. One available treatment …