RNA-binding proteins (RBPs) are key components in RNA metabolism, regulating the
temporal, spatial and functional dynamics of RNAs. Altering the expression of RBPs has …

Introduction Under specific conditions, a weak lead stimulus, or “prepulse”, can inhibit the
startling effects of a subsequent intense abrupt stimulus. This startle-inhibiting effect of the …

Protein quality-control, especially the removal of proteins with aberrant structures, has an
important role in maintaining the homeostasis of non-dividing neural cells. In addition to the …

Fragile X syndrome is caused by a loss of expression of the fragile X mental retardation
protein (FMRP). FMRP is a selective RNA-binding protein which forms a messenger …

The positive-strand RNA viruses initiate their amplification in the cell from a single genome
delivered by virion. This single RNA molecule needs to become involved in replication …

Neuronal plasticity requires actin cytoskeleton remodeling and local protein translation in
response to extracellular signals. Rho GTPase pathways control actin reorganization, while …

Fragile X syndrome (FXS) is the most common single gene (FMR1) disorder affecting
cognitive and behavioral function in humans. This syndrome is characterized by a cluster of …

Test batteries are commonly used to assess the behavioral phenotype of genetically
modified and inbred strains of mice. However, few systematic studies have been employed …

The loss of Fragile X mental retardation protein (FMRP) causes Fragile X syndrome, the
most common inherited mental retardation and single gene cause of autism. Although …

Background No animal models of autism spectrum disorders (ASD) with good construct
validity are currently available; using genetic models of pathologies characterized by ASD …